U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 21 - 30 of 9684 results

Status:
Investigational
Source:
INN:elarofiban
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Elarofiban is a novel nonpeptide glycoprotein IIb/IIIa (GPIIb/IIIa) antagonist. It inhibits thrombin-induced platelet aggregation in human gel-filtered platelets and platelet aggregation in human platelet-rich plasma (PRP) in response to collagen, arachidonic acid, ADP, and SFLLRN-NH(2). Elarofiban had adequate oral pharmacokinetics in dogs and excellent oral pharmacodynamics. Elarofiban has been in phase II clinical trials for the treatment of myocardial infarction and thrombosis. However, this research has been discontinued.
Status:
Investigational
Source:
NCT01871298: Not Applicable Interventional Completed Drug Abuse Illicit
(2014)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
INN:miloxacin
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Miloxacin, an antibacterial agent that was used in veterinary. This drug was also studied for the treatment of acute intestinitis. Experiments in vitro have shown that this compound exhibited significant activities against Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Proteus vulgaris, and less active against a Pseudomonas aeruginosa infection and inactive at the maximum test doses against a Streptococcus pyogenes infection. Information about the current use of miloxacin is not available.
Status:
Investigational
Source:
INN:DIBUPROL [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dibuprol is a muscle relaxant and choleretic drug.
Status:
Investigational
Source:
INN:democonazole
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Democonazole is the antimycotic agent.
Status:
Investigational
Source:
INN:nicothiazone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Nicothiazone (nicotinaldehyde thiosemicarbazone), an antituberculosis drug, was apparently responsible for inducing vacuoles in the corneal epithelium and thus caused discomfort and photophobia from corneal disturbance.
Status:
Investigational
Source:
J Magn Reson Imaging. 1997 May-Jun;7(3):523-7.: Phase 1 Human clinical trial Completed N/A
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Sprodiamide is a nonionic paramagnetic dysprosium chelate agent patented by Salutar, Inc.as diagnostic imaging contrast media. Compare with gadolinium-based agents Sprodiamide shows a stronger T2 effect and negligible T1 effect. This property makes Sprodiamide useful for blood volume imaging. In a preclinical model of reperfused ischemia of the rat intestine administration of Sprodiamide improved the contrast between the normal and ischemic intestine on T2-weighted images, and administration of both gadodiamide and Sprodiamide improved the contrast on T1- and T2-weighted images.
Status:
Investigational
Source:
INN:exaprolol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Exaprolol is a non-selective antagonist at beta-adrenoceptors exerting antiarrhythmic and local anesthetic activity. It inhibits the inotropic and chronotropic responses. Exaprolol liberates histamine from isolated mast cells and decreases the uptake of extracellular histamine. It acts on mast cells due to the direct and indirect ion exchange mechanism resulted in disproportion between histamine and granule liberation.
Status:
Investigational
Source:
INN:VALDIPROMIDE [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Valdipromide is an antidepressant.
Status:
Investigational
Source:
INN:CATRAMILAST [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Catramilast is imidazolone derivative patented by Janssen Pharmaceutica N.V. as PDE IV inhibitor for the treatment of allergic, atopic, and inflammatory diseases.