U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 17 - 32 of 7004 results

CHLORMERODRIN HG-203

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Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (RACEMIC)

HYODEOXYCHOLIC ACID

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Description

Hyodeoxycholic acid, also known as HDCA, is a secondary bile acid. Natural 6alpha-hydroxylated bile acids are receptor-specific activators of nuclear liver X receptor alpha (LXRalpha), a nuclear receptor regulating the expression of the cholesterol 7alpha-hydroxylase gene. AHRO-001 (Hyodeoxycholic acid) is in phase I clinical trials for the treatment of atherosclerosis. Through a complex signaling processes utilizing LXR receptors, the compound is designed to increase the efficiency of cholesterol efflux using the HDL cells, which act on all cholesterol in the arterial circulation as well as in the lipid core of plaque deposits in the artery walls. Use of AHRO-001 has shown no adverse effects on morbidity, mortality or toxicity and has been well tolerated at high doses.
Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)


Description

2′-Deoxycytidine (deoxyC) is one of the deoxy nucleosides, which after phosphorylation to dCTP is used to synthesize DNA via various DNA polymerases or reverse transcriptases. Deoxycytidine is phosphorylated by deoxycytidine kinase (dCK). This enzyme catalyzes the initial conversion of the nucleosides deoxyadenosine (dA), deoxyguanosine (dG), and deoxycytidine (dC) into their monophosphate forms, with subsequent phosphorylation to the triphosphate forms performed by additional enzymes.
Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Description

Porfiromycin is an N-methyl derivative of the antineoplastic antibiotic mitomycin-C initially isolated from Streptomyces ardus. Upon administration, the drug undergoes chemical or enzymatic reduction, followed by spontaneous loss of the tertiary methoxy (hydroxyl) group and formation of an aromatic indole system. Thus activated, porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks at guanosine residues. Porfiromycin was tested in phase III for head and neck carcinoma, however, its development was terminated.

Description

AR-42, also known as (S)-HDAC-42, is a phenylbutyrate-based histone deacetylase (HDAC) inhibitor. HDACs are enzymes that determine acetylation status of histones, thereby affecting chromatin structure and regulating the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. AR-42 possesses antitumor activity at multiple cellular levels. It is currently in Phase I/Ib trials for hematological malignancies and solid tumors.

NORADRENALINE, (+/-)-

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Status:
Investigational

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (ABSOLUTE)

TRIAMCINOLONE ACETONIDE 21-DIHYDROGEN PHOSPHATE

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Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
USAN/INN

Class (Stereo):
CHEMICAL (ABSOLUTE)