U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 11 - 20 of 7099 results

Status:
Investigational
Source:
INN:FLUTROLINE [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Flutroline, an antipsychotic drug that was studied to treat patients with schizophrenia. Clinical trials have shown that the drug was a safe, effective, and 20 mg and above offered the best potential for optimal clinical effectiveness. However, information about the further development of this drug is not available.
Status:
Investigational
Source:
INN:pentamorphone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Pentamorphone was developed as a highly potent opioid with rapid onset and short duration of action that has been reported to produce analgesia with limited depression of ventilation. Pentamorphone participated in a clinical trial for the management of postoperative pain. However, no acute cardiorespiratory changes were observed. The drug was ineffective for treating acute postoperative pain after major surgery. In addition, was shown that pentamorphone, 10 micrograms/kg, does not seem to offer any significant advantage over opioids currently used for anesthesia in patients undergoing elective coronary artery bypass grafting (CABG). That is why its further development was discontinued.
Status:
Investigational
Source:
INN:CANBISOL [INN]
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)

Canbisol is dihydroxyhexahydrodibenzo(b,d)pyran derivative patented by pharmaceutical company Eli Lilly and Co. as antihypertensive agent. At the dosages studied, Canbisol reduced food consumption by rats.
Status:
Investigational
Source:
INN:MESUPRINE [INN]
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Mesuprine is a β-adrenergic-receptor mimetic agent. It is a smooth muscle relaxant that prevents uterine contractility and premature labor.
Status:
Investigational
Source:
INN:LORTALAMINE [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Lortalamine is a new non-tricyclic anti-depressant compound. Lortalamine antagonizes in a dose-related manner reserpine-induced ptosis and hypothermia, and is far more potent than imipramine in this regard. The compound potentiates yohimbine toxicity in mice and, in the anesthetized dog, diminishes the tyramine pressure response while increasing the response to norepinephrine. These results would indicate the capacity for lortalamine to act as a norepinephrine uptake inhibitor, and indeed, lortalamine is more potent than imipramine in inhibiting norepinephrine uptake by rat brain cortex slices. Lortalamine does not inhibit serotonin uptake by rat midbrain slices. Lortalamine has a high affinity and high selectivity for the norepinephrine transporter. Lortalamine treated dogs showed, progressively, bilateral mydriasis, conjunctivitis, epiphora, corneal oedema and corneal erosions.
Status:
Investigational
Source:
USAN:IODOANTIPYRINE I 131 [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iodoantipyrine I-131 is a radiopharmaceutical nonsteroid anti-inflammatory compound evaluated for coronary blood flow measure and as a total body water marker. In vivo results suggested that soon after injection of 4-I131 AP (Iodoantipyrine I-131) in rats , significant and increasing quantities of the I131 tracer were detached from the antipyrine molecule in a form which is more diffusible than 4-I131 AP. Evidence for a similar phenomenon was seen in other species. There were qualitative differences in the behavior of antipyrine and 4-I131 AP when injected in animals, and these may invalidate the use of 4-I131 AP as a substitute for antipyrine in studies of body composition.
Status:
Investigational
Source:
INN:MECIADANOL [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Meciadanol (O-methyl-3(+)catechin or Zy 15029), a synthetic flavonoid, is an inhibitor of histamine-forming enzyme histidine decarboxylase. It prevents stimulus-dependent gastric acid secretion. Meciadanol was shown to have a marked protective action against experimental peptic ulceration.
Status:
Investigational
Source:
USAN:LYCETAMINE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Lycetamine is an antibacterial compound.
Status:
Investigational
Source:
INN:CIPROXIMIDE [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Cyproximide is a psychoactive drug discovered by American Cyanamid company. The drug exhibited activity as a central nervous system depressant and was claimed to be useful as a tranquilizing agent, hypnotic agent or muscle relaxant. The phenobarbital-like activity of cyproximide after intraperitoneal administration was demonstrated in rod traversal, clinging and righting reflex tests in mice. In addition to CNS depressant activity, cyproximide had a mild stimulant and antidepressant effects, which were shown by the restoration of exploratory behavior and an increase in locomotor activity in mice. Chronic administration of the drug led to a greater incidence of proliferative lesions in the liver of treated rats; however, the incidence of hepatocellular neoplasms was the same in treated and control rats.
Status:
Investigational
Source:
INN:bolenol
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Bolenol is a synthetic anabolic steroid that was never marketed.

Showing 11 - 20 of 7099 results