U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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GSK 525768A is inactive enantiomer of BET inhibitor, compound I-BET (GSK525762A). It was used as a negative controls in studies of I-BET.
Status:
Investigational
Source:
INN:hydromorphinol
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Hydromorphinol, an opioid, and is a derivative of morphine and possesses similar properties: sedation, analgesia, and respiratory depression. Hydromorphinol is under the control according to US Single Convention 1961.
Status:
Investigational
Source:
NCT02322021: Phase 2 Interventional Completed Alzheimer Disease
(2014)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT01053962: Phase 2 Interventional Completed Chronic Idiopathic Constipation
(2010)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Pirnabine is the synthetic dibenzopyran drug. It was developed as anti-glaucoma drug.
Status:
Investigational
Source:
INN:YOHIMBIC ACID [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Yohimbinic acid, also known as yohimbic acid is an indole alkaloid, which was isolated from dried roots of Rauwolfia serpentina. Yohimbinic acid is a potent inhibitor of a human DNA Topoisomerase I and can inhibit cancer cells growth.
Status:
Investigational
Source:
INN:DISERMOLIDE [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Disermolide (discodermolide) is the immunosuppressant and antineoplastic agent. The marine natural product discodermolide was first isolated in 1990 from the deep-water Caribbean sponge Discodermia dissoluta. It attacks cancer cells in a similar way to the successful cancer drug Taxol that has become the best-selling anticancer drug in history. Discodermolide is a microtubule-stabilizing agent with potential for the treatment of taxol-refractory malignancies. Discodermolide is a drug that functions as an immunosuppressant and induces G2/M phase cell-cycle arrest in lymphoid and non-lymphoid cells. The cytotoxicity of discodermolide cause cell-cycle arrest by mitosis and an important alteration at the level of microtubules. Discodermolide is a potent inducer of accelerated senescence. At present, Phase I trials with discodermolide has been discontinued as a consequence of unsafe efficacy and toxicity results.
Status:
Investigational
Source:
J Gynecol Obstet Biol Reprod (Paris). 1993;22(6):659-66.: Not Applicable Human clinical trial Completed N/A
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT01889212: Not Applicable Interventional Terminated Lung Cancer
(2013)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:emilium tosilate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Emilium is an antiarrhythmic agent and cardiac depressant.
Status:
Investigational
Source:
NCT04692688: Phase 2 Interventional Not yet recruiting Diabetic Retinopathy
(2021)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)