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Details

Stereochemistry ACHIRAL
Molecular Formula C6H11N3
Molecular Weight 125.1716
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N.ALPHA.-METHYLHISTAMINE

SMILES

CNCCC1=CN=CN1

InChI

InChIKey=PHSPJQZRQAJPPF-UHFFFAOYSA-N
InChI=1S/C6H11N3/c1-7-3-2-6-4-8-5-9-6/h4-5,7H,2-3H2,1H3,(H,8,9)

HIDE SMILES / InChI

Molecular Formula C6H11N3
Molecular Weight 125.1716
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

alpha-N-methyl-histamine is a metabolite of histamine that plays an important role in several (patho) physiological processes. alpha-N-methyl-histamine is being a potent agonist of histamine H3 receptor can be used as an effective therapeutic alternative in migraine patients.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.4 nM [Kd]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
PubMed

PubMed

TitleDatePubMed
Characterization and tissue distribution of H3 histamine receptors in guinea pigs by N alpha-methylhistamine.
1990 May 16
Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c.
2011 Dec
Review of commonly used clinical pathology parameters for general gastrointestinal disease with emphasis on small animals.
2014 Jan
N alpha methyl histamine versus propranolol in migraine prophylaxis.
2014 Mar
What a Difference a Methyl Group Makes: The Selectivity of Monoamine Oxidase B Towards Histamine and N-Methylhistamine.
2017 Feb 24
Patents

Patents

Sample Use Guides

In Vivo Use Guide
in migraine prophylaxis: 1 to 3 ug twice a week
Route of Administration: subcutaneous
Substance Class Chemical
Created
by admin
on Tue Oct 22 13:36:41 UTC 2019
Edited
by admin
on Tue Oct 22 13:36:41 UTC 2019
Record UNII
Y7QR253130
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
N.ALPHA.-METHYLHISTAMINE
Systematic Name English
2-(1H-IMIDAZOL-4-YL)-N-METHYLETHANAMINE
Systematic Name English
4-(2-METHYLAMINOETHYL)-1H-IMIDAZOLE
Systematic Name English
N'-METHYLHISTAMINE
Systematic Name English
1H-IMIDAZOLE-4-ETHANAMINE, N-METHYL-
Systematic Name English
1H-IMIDAZOLE-5-ETHANAMINE, N-METHYL-
Systematic Name English
N-METHYLHISTAMINE
Systematic Name English
4-(2-(N-METHYLAMINO)ETHYL)IMIDAZOLE
Systematic Name English
4-(2-METHYLAMINOETHYL)IMIDAZOLE
Systematic Name English
METHYLHISTAMINE
Systematic Name English
IMIDAZOLE, 4-(2-(METHYLAMINO)ETHYL)-
Systematic Name English
IMIDAZOLE, 4(OR 5)-(2-(METHYLAMINO)ETHYL)-
Common Name English
Code System Code Type Description
PUBCHEM
912
Created by admin on Tue Oct 22 13:36:41 UTC 2019 , Edited by admin on Tue Oct 22 13:36:41 UTC 2019
PRIMARY
CAS
673-50-7
Created by admin on Tue Oct 22 13:36:41 UTC 2019 , Edited by admin on Tue Oct 22 13:36:41 UTC 2019
PRIMARY
EPA CompTox
673-50-7
Created by admin on Tue Oct 22 13:36:41 UTC 2019 , Edited by admin on Tue Oct 22 13:36:41 UTC 2019
PRIMARY