U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H16ClF3N6O2
Molecular Weight 452.8182
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DPOC-4088

SMILES

c1ccnc(c1)C(CN=c2c(=O)n(CC(=NCc3c(cccn3)F)O)c(c[nH]2)Cl)(F)F

InChI

InChIKey=AATHXZYXWMKUFC-UHFFFAOYSA-N
InChI=1S/C19H16ClF3N6O2/c20-15-9-27-17(28-11-19(22,23)14-5-1-2-6-25-14)18(31)29(15)10-16(30)26-8-13-12(21)4-3-7-24-13/h1-7,9H,8,10-11H2,(H,26,30)(H,27,28)

HIDE SMILES / InChI

Molecular Formula C19H16ClF3N6O2
Molecular Weight 452.8182
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Jun 26 16:40:39 UTC 2021
Edited
by admin
on Sat Jun 26 16:40:39 UTC 2021
Record UNII
S6MPG81Y84
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DPOC-4088
Common Name English
1(2H)-PYRAZINEACETAMIDE, 6-CHLORO-3-((2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL)AMINO)-N-((3-FLUORO-2-PYRIDINYL)METHYL)-2-OXO-
Systematic Name English
2-(6-CHLORO-3-((2,2-DIFLUORO-2-(2-PYRIDYL)ETHYL)AMINO)-2-OXO-PYRAZIN-1-YL)-N-((3-FLUORO-2-PYRIDYL)METHYL)ACETAMIDE
Systematic Name English
2-(3-((2,2-DIFLUORO-2-(2-PYRIDYL)ETHYL)AMINO)-6-CHLORO-2-OXOHYDROPYRAZINYL)-N-((3-FLUORO(2-PYRIDYL))METHYL)ACETAMIDE
Systematic Name English
DP-4088
Code English
DPOC 4088
Code English
Code System Code Type Description
MANUFACTURER PRODUCT INFORMATION
DPOC-4088
Created by admin on Sat Jun 26 16:40:39 UTC 2021 , Edited by admin on Sat Jun 26 16:40:39 UTC 2021
PRIMARY CAS Number: 312904-62-4
FDA UNII
S6MPG81Y84
Created by admin on Sat Jun 26 16:40:39 UTC 2021 , Edited by admin on Sat Jun 26 16:40:39 UTC 2021
PRIMARY
CLINICAL_TRIALS.GOV
DPOC-4088
Created by admin on Sat Jun 26 16:40:39 UTC 2021 , Edited by admin on Sat Jun 26 16:40:39 UTC 2021
PRIMARY A study to investigate the concentrations of a new drug DPOC-4088 in blood, and to study the effect of this drug on blood clotting parameters. Furthermore the relation between the blood concentrations and the blood clotting effect will be investigated. Safety will be investigated as well. The objective of these investigations is to determine the optimal dose of DPOC-4088 that, achieves a relevant increase in a specific blood clotting parameter (the ecarin clotting time) without safety concerns.
CAS
312904-62-4
Created by admin on Sat Jun 26 16:40:39 UTC 2021 , Edited by admin on Sat Jun 26 16:40:39 UTC 2021
PRIMARY
PUBCHEM
9955534
Created by admin on Sat Jun 26 16:40:39 UTC 2021 , Edited by admin on Sat Jun 26 16:40:39 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Class: Antithrombotic, Small molecule; Mechanism of Action: Thrombin inhibitor; Highest Development Phase: Phase I Blood coagulation disorder; Most Recent Event: 13 Apr 2016 - This programme is still active.