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Details

Stereochemistry ACHIRAL
Molecular Formula C2H6N2O
Molecular Weight 74.0818
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-NITROSODIMETHYLAMINE

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N
InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula C2H6N2O
Molecular Weight 74.0818
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Meat consumption and risk of stomach cancer in Uruguay: a case-control study.
2001
O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer.
2001
[Morphologic study of renal carcinogenesis in rats induced by dimethylnitrosamine].
2001
Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract.
2001
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor.
2001 Apr
Changes in the expression of cytochrome P450 2E1 and the activity of carcinogen-metabolizing enzymes in Schistosoma haematobium-infected human bladder tissues.
2001 Apr 12
The influence of very low doses of N-nitrosodimethylamine (NDMA) on the apoptosis of rat neutrophils in vivo. The role of reactive oxygen species.
2001 Aug 13
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.
2001 Dec
Carcinogenicity assays of wood dust and wood additives in rats exposed by long-term inhalation.
2001 Mar
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.
2001 Mar
Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt.
2001 Mar 9
SOral gene therapy.
2001 May
Effects of octreotide on intestinal transit and bacterial translocation in conscious rats with portal hypertension and liver fibrosis.
2001 Nov
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
2001 Nov
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase.
2001 Nov 1
[The role of xanthine oxidase in the cytotoxic action of nitrates and nitrites].
2001 Nov-Dec
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.
2001 Nov-Dec
Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia.
2001 Oct
Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.
2001 Oct 17
Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus.
2001 Sep
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.
2001 Sep 15
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.
2001 Sep-Oct
A kinetic model of N-nitrosodimethylamine (NDMA) formation during water chlorination/chloramination.
2002
Mechanistic studies of N-nitrosodimethylamine (NDMA) formation in chlorinated drinking water.
2002 Apr
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.
2002 Apr
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
2002 Aug
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.
2002 Jul
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
2002 Jun
DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.
2002 Mar 20
Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis.
2002 May
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.
2002 May
Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.
2002 May 22
Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats.
2002 May 24
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.
2002 Oct 11
Monitoring of nitrite and N-nitrosamine levels in irradiated pork sausage.
2002 Sep
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol.
2002 Sep
Patents

Patents

Substance Class Chemical
Created
by admin
on Mon Oct 21 21:20:50 UTC 2019
Edited
by admin
on Mon Oct 21 21:20:50 UTC 2019
Record UNII
M43H21IO8R
Record Status Validated (UNII)
Record Version
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Name Type Language
N-NITROSODIMETHYLAMINE
HSDB   MI  
Systematic Name English
DIMETHYLNITROSAMINE
Common Name English
N-NITROSODIMETHYLAMINE [HSDB]
Common Name English
DMN
Common Name English
N-NITROSODIMETHYLAMINE [IARC]
Common Name English
NDMA
Common Name English
DMNA
Common Name English
METHANAMINE, N-METHYL-N-NITROSO-
Systematic Name English
NSC-23226
Code English
NMDA (GENOTOXIC)
Common Name English
N-NITROSODIMETHYLAMINE [MI]
Common Name English
N-METHYL-N-NITROSOMETHANAMINE
Systematic Name English
Classification Tree Code System Code
IARC <i>N</i>-Nitrosodimethylamine
NCI_THESAURUS C45398
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
Code System Code Type Description
MERCK INDEX
M7994
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY Merck Index
WIKIPEDIA
N-NITROSODIMETHYLAMINE
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
HSDB
62-75-9
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
EPA CompTox
62-75-9
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
MESH
D004128
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
PUBCHEM
6124
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
ECHA (EC/EINECS)
200-549-8
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
NCI_THESAURUS
C44417
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
CAS
62-75-9
Created by admin on Mon Oct 21 21:20:50 UTC 2019 , Edited by admin on Mon Oct 21 21:20:50 UTC 2019
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT -> IMPURITY
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is part of a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.