N-NITROSODIMETHYLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N

InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Meat consumption and risk of stomach cancer in Uruguay: a case-control study.	2001	11962244
O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer.	2001	11588901
[Morphologic study of renal carcinogenesis in rats induced by dimethylnitrosamine].	2001	11317540
Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract.	2001	11276828
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor.	2001 Apr	11285187
Changes in the expression of cytochrome P450 2E1 and the activity of carcinogen-metabolizing enzymes in Schistosoma haematobium-infected human bladder tissues.	2001 Apr 12	11311457
The influence of very low doses of N-nitrosodimethylamine (NDMA) on the apoptosis of rat neutrophils in vivo. The role of reactive oxygen species.	2001 Aug 13	11551432
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.	2001 Dec	11738098
Carcinogenicity assays of wood dust and wood additives in rats exposed by long-term inhalation.	2001 Mar	11317703
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.	2001 Mar	11303587
Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt.	2001 Mar 9	11269598
SOral gene therapy.	2001 May	11301115
Effects of octreotide on intestinal transit and bacterial translocation in conscious rats with portal hypertension and liver fibrosis.	2001 Nov	11713937
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Nov	11605027
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase.	2001 Nov 1	11600130
[The role of xanthine oxidase in the cytotoxic action of nitrates and nitrites].	2001 Nov-Dec	12199068
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.	2001 Nov-Dec	11911287
Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia.	2001 Oct	11599795
Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.	2001 Oct 17	11604475
Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus.	2001 Sep	11568970
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.	2001 Sep 15	11641050
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.	2001 Sep-Oct	11601460
A kinetic model of N-nitrosodimethylamine (NDMA) formation during water chlorination/chloramination.	2002	12227605
Mechanistic studies of N-nitrosodimethylamine (NDMA) formation in chlorinated drinking water.	2002 Apr	11993764
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	2002 Apr	11960914
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.	2002 Aug	12198369
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.	2002 Jul	12149139
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.	2002 Jun	12055599
DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.	2002 Mar 20	11890936
Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis.	2002 May	12003998
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.	2002 May	11971997
Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.	2002 May 22	12023046
Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats.	2002 May 24	11985890
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.	2002 Oct 11	12270756
Monitoring of nitrite and N-nitrosamine levels in irradiated pork sausage.	2002 Sep	12233865
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol.	2002 Sep	12189197

Patents

Substance Class	Chemical Created by `admin` on `Mon Oct 21 21:20:50 UTC 2019` Edited by `admin` on `Mon Oct 21 21:20:50 UTC 2019`
Record UNII	M43H21IO8R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-NITROSODIMETHYLAMINE

Systematic Name

English

DIMETHYLNITROSAMINE

Common Name

English

N-NITROSODIMETHYLAMINE [HSDB]

Common Name

English

DMN

Common Name

English

N-NITROSODIMETHYLAMINE [IARC]

Common Name

English

NDMA

Common Name

English

DMNA

Common Name

English

METHANAMINE, N-METHYL-N-NITROSO-

Systematic Name

English

NSC-23226

Code

English

NMDA (GENOTOXIC)

Common Name

English

N-NITROSODIMETHYLAMINE [MI]

Common Name

English

N-METHYL-N-NITROSOMETHANAMINE

Systematic Name

English

Classification Tree Code System Code

IARC

<i>N</i>-Nitrosodimethylamine

NCI_THESAURUS

C45398