U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C12H24O11
Molecular Weight 344.3124
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LACTITOL

SMILES

OC[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO

InChI

InChIKey=VQHSOMBJVWLPSR-JVCRWLNRSA-N
InChI=1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-/m0/s1

HIDE SMILES / InChI

Molecular Formula C12H24O11
Molecular Weight 344.3124
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 9 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Lactitol is a sugar alcohol. This ingredient has been determined to be GRAS for specified uses as a direct food additive and foods containing lactitol are eligible for a health claim related to dental caries. Lactitol is used as an oral powder or solution in the management of hepatic encephalopathy and in case of short-term treatment of occasional constipation. Intestinal flora of large intestine is metabolize lactitol to low-molecular organic acid, which leads to an increase in osmotic pressure in intestine, increase in volume of fecal masses bowel function normalization. This drug might cause abdominal discomfort, especially flatulence and abdominal pain rarely or sometimes abdominal distension. These effects tend to diminish or disappear after a few days of regular intake of the drug. Since 'antacids and neomycin can neutralize ' acidifying effect of lactitol on stool, they should not be co-administered with lactitol in cirrhotic patients with hepatic encephalopathy; however both substances do not alter the 'laxative effect in patients with constipation.

Originator

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Importal
Primary
Importal
PubMed

PubMed

TitleDatePubMed
Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties.
2003 Dec
Characterization of the bga1-encoded glycoside hydrolase family 35 beta-galactosidase of Hypocrea jecorina with galacto-beta-D-galactanase activity.
2007 Apr
Constipation in adults.
2007 Aug 1
The treatment of hepatic encephalopathy.
2007 Dec
Threshold for transitory diarrhea induced by ingestion of xylitol and lactitol in young male and female adults.
2007 Feb
Anemia impairs small intestinal absorption measured by intestinal permeability in children.
2007 Jan
A study of the properties of tablets from the mixtures of directly compressible starch and directly compressible lactitol.
2007 Jul
The trans-sialidase from Trypanosoma cruzi efficiently transfers alpha-(2-->3)-linked N-glycolylneuraminic acid to terminal beta-galactosyl units.
2007 Nov 26
[A case of recurrent pneumatosis cystoides intestinalis associated with recurrent pneumoperitoneum].
2007 Sep
Effects of low doses of lactitol on faecal microflora, pH, short chain fatty acids and gastrointestinal symptomology.
2007 Sep
Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study.
2007 Sep 4
Ecological characterization of the colonic microbiota of normal and diarrheic dogs.
2008
Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis.
2008
Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies.
2008
[Influence of the bifidobacteria and lactitol containing products on lypoperoxidation processes and intestinal microflora].
2008
Rifaximin for the treatment of hepatic encephalopathy.
2008 Aug
Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland.
2008 Dec 31
Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, double-blind, randomized, placebo-controlled study.
2008 Jan 15
Characteristic fragmentation patterns of the trimethylsilyl and trimethylsilyl-oxime derivatives of various saccharides as obtained by gas chromatography coupled to ion-trap mass spectrometry.
2008 Jan 4
Xylitol-supplemented nutrition enhances bacterial killing and prolongs survival of rats in experimental pneumococcal sepsis.
2008 Mar 11
Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence.
2008 May
Treatment of minimal hepatic encephalopathy.
2008 Nov
Intestinal metabolism of weaned piglets fed a typical United States or European diet with or without supplementation of tributyrin and lactitol.
2008 Nov
[Prebiotic lactitol as a component of biopreparation from aerobic bacilli].
2008 Nov-Dec
Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days.
2009
The role of rifaximin in the treatment and chemoprophylaxis of travelers' diarrhea.
2009
Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters.
2009 Feb
Standards of medical care in diabetes--2009.
2009 Jan
Suppressive response of confections containing the extractive from leaves of Morus Alba on postprandial blood glucose and insulin in healthy human subjects.
2009 Jul 14
Current trends in the treatment of hepatic encephalopathy.
2009 Jun
Polyols as filler-binders for disintegrating tablets prepared by direct compaction.
2009 Jun
[Elderly hereditary hemorrhagic telangiectasia female with portosystemic encephalopathy].
2009 May
Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice.
2009 Nov 30
Sugar alcohols, caries incidence, and remineralization of caries lesions: a literature review.
2010
Idiopathic proximal hemimegacolon in an adult woman.
2010 Apr
Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols.
2010 Apr 15
Successful drug development despite adverse preclinical findings part 2: examples.
2010 Dec
Microbial and bioconversion production of D-xylitol and its detection and application.
2010 Dec 15
Duodenal administered seal oil for patients with subjective food hypersensitivity: an explorative open pilot study.
2010 Dec 6
Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults.
2010 Feb 5
Standards of medical care in diabetes--2010.
2010 Jan
Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase.
2010 Jul
Constipation in adults.
2010 Jul 5
Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures.
2010 Jun
Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model.
2010 Jun
Pharmacotherapy for hepatic encephalopathy.
2010 Jun 18
Recombinant human granulocyte colony stimulating factor pre-screening and screening of stabilizing carbohydrates and polyols.
2010 Mar 15
Lactitol or lactulose in the treatment of chronic constipation: result of a systematic.
2010 Nov
Differences between reversible (self-association) and irreversible aggregation of rHuG-CSF in carbohydrate and polyol formulations.
2010 Nov
Current and emerging strategies for treating hepatic encephalopathy.
2010 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Initial dose - 20 g at once during 4-5 days. Next, 10 g per day.
Route of Administration: Oral
In Vitro Use Guide
The species of bifidobacteria, which were detected in vessel of each fermentation after adaptation to an Lactitol 1% (wt/vol): Bifidobacterium adolescentis, B. bifidum, B. longum, B. dentium and B. catenulatum. B. angulatum, B. breve and B. infantis were not detected.
Substance Class Chemical
Created
by admin
on Tue Oct 22 05:34:03 UTC 2019
Edited
by admin
on Tue Oct 22 05:34:03 UTC 2019
Record UNII
L2B0WJF7ZY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LACTITOL
INCI   INN   MI   WHO-DD  
INN   INCI  
Official Name English
LACTITOL ANHYDROUS
Common Name English
LACTOBIOSIT
Common Name English
MIRUHEN
Common Name English
LACTITOL ACM 50
Common Name English
NSC-231323
Code English
E-966
Code English
IMPORTAL
Brand Name English
4-O-.BETA.-D-GALACTOPYRANOSYL-D-GLUCITOL
Common Name English
LACTY (SACCHARIDE)
Common Name English
INS-966
Code English
D-LACTITOL
Common Name English
MILCHEN
Common Name English
LACTITOL [MI]
Common Name English
LACTITOL [WHO-DD]
Common Name English
LACTOSITOL
Common Name English
LACTITOL [INN]
Common Name English
FINLAC DC
Common Name English
LACTOSIT
Common Name English
INS NO.966
Code English
LACTITOL [INCI]
Common Name English
Classification Tree Code System Code
WHO-VATC QA06AD12
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
JECFA EVALUATION INS-966
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
WHO-ATC A06AD12
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
NCI_THESAURUS C283
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
CODEX ALIMENTARIUS (GSFA) INS-966
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
Code System Code Type Description
MERCK INDEX
M6659
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY Merck Index
ChEMBL
CHEMBL296306
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
EVMPD
SUB126857
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
HSDB
585-86-4
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
EU FOOD ADDITIVES
E 966
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
CAS
585-86-4
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
WIKIPEDIA
LACTITOL
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
MESH
C014635
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
EPA CompTox
585-86-4
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
PUBCHEM
157355
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
EVMPD
SUB08385MIG
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
ECHA (EC/EINECS)
209-566-5
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
RXCUI
28395
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY RxNorm
JECFA MONOGRAPH
INS-966
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
INN
6414
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
NCI_THESAURUS
C81025
Created by admin on Tue Oct 22 05:34:03 UTC 2019 , Edited by admin on Tue Oct 22 05:34:03 UTC 2019
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY