U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Mon Oct 21 20:29:37 UTC 2019
Edited
by admin
on Mon Oct 21 20:29:37 UTC 2019
Protein Sub Type
Sequence Type COMPLETE
Record UNII
I81U7H57XI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OAT-1
Common Name English
SOLUTE CARRIER FAMILY 22 MEMBER 6
Common Name English
MGC45260
Common Name English
HOAT-1
Common Name English
OAT1
Common Name English
PAH TRANSPORTER
Common Name English
RENAL ORGANIC ANION TRANSPORTER 1
Common Name English
PAHT
Common Name English
FLJ55736
Common Name English
HOAT1
Common Name English
ROAT1
Common Name English
ROAT-1
Common Name English
SLC22A6
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL SLC22A6
Created by admin on Mon Oct 21 20:29:38 UTC 2019 , Edited by admin on Mon Oct 21 20:29:38 UTC 2019
Code System Code Type Description
UNIPROT
Q4U2R8
Created by admin on Mon Oct 21 20:29:38 UTC 2019 , Edited by admin on Mon Oct 21 20:29:38 UTC 2019
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_39
N 1_56
N 1_92
N 1_97
N 1_113
Related Record Type Details
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Based on in vitro studies, lesinurad is a weak inhibitor of OATP1B1, OCT1, OAT1, and OAT3.
WEAK
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
Based on in vitro studies, lesinurad is a substrate of OAT1 and OAT3.
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
May cause kidney toxicity. Excretion from kidney proximal tubules unclear
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
WEAK
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
May cause renal toxicity
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR->OFF-TARGET
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL