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Description

Aldeyra’s lead product candidate, reproxalap (formerly ADX 102 or NS-2), is a small molecule RASP (Reactive Aldehyde Species) inhibitor in Phase 3 clinical development for the treatment of dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjögren-Larsson syndrome. NS-2 has been tested in a variety of in vitro and preclinical models, and has demonstrated the ability to trap free aldehydes, diminish inflammation, reduce healing time, protect key cellular constituents from aldehyde damage, and lower the potential for scarring or fibrosis. NS-2 has been tested in a variety of toxicity studies in animals and appears to be generally safe and well tolerated. NS-2 has an orphan drug status for the treatment of Sjogren-Larsson syndrome.

Approval Year

Sample Use Guides

In Vivo Use Guide
Non-infectious Anterior Uveitis: NS-2 ophthalmic drops (0.5%) in the affected eye
Route of Administration: Topical
Substance Class
Concept
Record UNII
F0GIZ22IJH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
REPROXALAP
INN   USAN  
Official Name English
ADX-102
Code English
REPROXALAP [INN]
Common Name English
ALD-102
Code English
REPROXALAP [USAN]
Common Name English
NS-2
Common Name English
2-QUINOLINEMETHANOL, 3-AMINO-6-CHLORO-.ALPHA.,.ALPHA.-DIMETHYL-
Systematic Name English
NS2
Common Name English
2-(3-AMINO-6-CHLOROQUINOLIN-2-YL)-PROPAN-2-OL
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Mon Oct 21 20:07:31 UTC 2019 , Edited by admin on Mon Oct 21 20:07:31 UTC 2019
FDA ORPHAN DRUG 530116
Created by admin on Mon Oct 21 20:07:31 UTC 2019 , Edited by admin on Mon Oct 21 20:07:31 UTC 2019
Code System Code Type Description
NCI_THESAURUS
C152196
Created by admin on Mon Oct 21 20:07:31 UTC 2019 , Edited by admin on Mon Oct 21 20:07:31 UTC 2019
PRIMARY
EVMPD
SUB197068
Created by admin on Mon Oct 21 20:07:31 UTC 2019 , Edited by admin on Mon Oct 21 20:07:31 UTC 2019
PRIMARY
PUBCHEM
16088030
Created by admin on Mon Oct 21 20:07:31 UTC 2019 , Edited by admin on Mon Oct 21 20:07:31 UTC 2019
PRIMARY
CAS
916056-79-6
Created by admin on Mon Oct 21 20:07:31 UTC 2019 , Edited by admin on Mon Oct 21 20:07:31 UTC 2019
PRIMARY
INN
10698
Created by admin on Mon Oct 21 20:07:31 UTC 2019 , Edited by admin on Mon Oct 21 20:07:31 UTC 2019
PRIMARY
This is a non-substance concept
Related Record Type Details
ACTIVE MOIETY
This is a non-substance concept