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Approval Year

Substance Class
Concept
Record UNII
DW4CE8MKS9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AVDORALIMAB
INN  
Official Name English
NNC-0215-0384
Code English
ANTI-C5AR-215
Common Name English
NN-8210
Code English
AVDORALIMAB [INN]
Common Name English
IPH-5401
Code English
IPH5401
Common Name English
Code System Code Type Description
INN
11081
Created by admin on Mon Oct 21 20:17:01 UTC 2019 , Edited by admin on Mon Oct 21 20:17:01 UTC 2019
PRIMARY
CAS
2226393-85-5
Created by admin on Mon Oct 21 20:17:01 UTC 2019 , Edited by admin on Mon Oct 21 20:17:01 UTC 2019
PRIMARY
This is a non-substance concept
Related Record Type Details
TARGET -> INHIBITOR
IPH5401 is a therapeutic human antibody that specifically binds and blocks C5a receptors (C5aR) expressed on subsets of myeloid-derived suppressor cells (MDSC) and neutrophils. IPH5401 blocks the binding of C5a to C5aR, thereby reducing the accumulation and activation of MDSC and neutrophils in tumors. Treatment with IPH5401 may unleash anti-tumor activities of T cells and NK cells.
Related Record Type Details
ACTIVE MOIETY
This is a non-substance concept