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Details

Stereochemistry ACHIRAL
Molecular Formula C17H15ClO4
Molecular Weight 318.752
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FENOFIBRIC ACID

SMILES

CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C(O)=O

InChI

InChIKey=MQOBSOSZFYZQOK-UHFFFAOYSA-N
InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula C17H15ClO4
Molecular Weight 318.752
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
FIBRICOR
PubMed

PubMed

TitleDatePubMed
Photosensitization of thymine nucleobase by benzophenone derivatives as models for photoinduced DNA damage: Paterno-Büchi vs energy and electron transfer processes.
2004 Jul
A new fenofibrate formulation: results of six single-dose, clinical studies of bioavailability under fed and fasting conditions.
2004 Sep
Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans.
2004 Sep
Fenofibric acid.
2005 Feb
Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes.
2005 Jan
Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells.
2005 Jul 1
Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.
2005 Oct 3
Bezafibrate increases very-long-chain acyl-CoA dehydrogenase protein and mRNA expression in deficient fibroblasts and is a potential therapy for fatty acid oxidation disorders.
2005 Sep 15
Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.
2005 Sep 15
Fenofibrate: a novel formulation (Triglide) in the treatment of lipid disorders: a review.
2006
The PPAR-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs.
2006 May
Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro.
2006 Nov 24
The transfer of a LC-UV method for the determination of fenofibrate and fenofibric acid in Lidoses: use of total error as decision criterion.
2006 Sep 11
Activating effect of benzbromarone, a uricosuric drug, on peroxisome proliferator-activated receptors.
2007
Determination of fenofibric acid concentrations by HPLC after anion exchange solid-phase extraction from human serum.
2007 Apr
Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.
2007 Aug
Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid.
2007 Aug
Effects of peroxisome proliferator-activated receptor activation on gonadotropin transcription and cell mitosis induced by bone morphogenetic proteins in mouse gonadotrope LbetaT2 cells.
2007 Jul
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.
2007 May
Update on the clinical utility of fenofibrate in mixed dyslipidemias: mechanisms of action and rational prescribing.
2008
Statins Activate Human PPARalpha Promoter and Increase PPARalpha mRNA Expression and Activation in HepG2 Cells.
2008
Nanocrystal technology, drug delivery and clinical applications.
2008
Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme.
2008
Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems.
2008
Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
2008 Apr 28
A novel PPARalpha agonist ameliorates insulin resistance in dogs fed a high-fat diet.
2008 May
An automated method for the simultaneous determination of pravastatin, 3-hydroxy isomeric metabolite, pravalactone and fenofibric acid in human plasma by sensitive liquid chromatography combined with diode array and tandem mass spectrometry detection.
2008 May 2
Fenofibrate set to benefit from new research on its active metabolite, fenofibric acid.
2008 May-Jun
Fenofibric acid: in combination therapy in the treatment of mixed dyslipidemia.
2009
MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation.
2009
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression.
2009 Apr
Fenofibrate-loaded PLGA microparticles: effects on ischemic stroke.
2009 Apr 11
Advances in the medical treatment of diabetic retinopathy.
2009 Aug
Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.
2009 Aug
Capecitabine-induced severe hypertriglyceridaemia and diabetes: a case report and review of the literature.
2009 Dec
Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia.
2009 Feb 15
Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study.
2009 Jan
ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans.
2009 Jan
Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.
2009 Jun
Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics.
2009 Jun
Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein.
2009 Jun
Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: a phase 3 study.
2009 May
Fenofibric Acid (trilipix).
2009 May 4
In vitro glucuronidation of fenofibric acid by human UDP-glucuronosyltransferases and liver microsomes.
2009 Nov
Myopathy with statin-fibrate combination therapy: clinical considerations.
2009 Sep
Determination of fenofibric acid in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry: application to a bioequivalence study.
2009 Sep
Probing the fibrate binding specificity of rat liver fatty acid binding protein.
2009 Sep 10
Year two assessment of fenofibric acid and moderate-dose statin combination: a phase 3, open-label, extension study.
2010
Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain.
2010 Apr
Ecotoxicity assessment of lipid regulators in water and biologically treated wastewater using three aquatic organisms.
2010 Jan
Substance Class Chemical
Created
by admin
on Mon Oct 21 23:48:50 UTC 2019
Edited
by admin
on Mon Oct 21 23:48:50 UTC 2019
Record UNII
BGF9MN2HU1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FENOFIBRIC ACID
ORANGE BOOK   VANDF   WHO-DD  
Common Name English
FIBRICOR
Brand Name English
FENOFIBRIC ACID [ORANGE BOOK]
Common Name English
FENOFIBRATE FREE ACID [MI]
Common Name English
FENOFIBRATE RELATED COMPOUND B [USP-RS]
Common Name English
FENOFIBRIC ACID [WHO-DD]
Common Name English
PROPANOIC ACID, 2-(4-(4-CHLOROBENZOYL)PHENOXY)-2-METHYL-
Common Name English
LF-153
Code English
FENOFIBRIC ACID [VANDF]
Common Name English
NSC-281318
Code English
FENOFIBRATE RELATED COMPOUND B
USP-RS  
Common Name English
Classification Tree Code System Code
NDF-RT N0000175596
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
NCI_THESAURUS C98150
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
Code System Code Type Description
RXCUI
24852
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY RxNorm
EPA CompTox
42017-89-0
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
PUBCHEM
64929
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
EVMPD
SUB34521
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
CAS
42017-89-0
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
WIKIPEDIA
Fenofibric acid
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
MERCK INDEX
M5279
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
ChEMBL
CHEMBL981
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
NCI_THESAURUS
C83804
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
MESH
C006012
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
ECHA (EC/EINECS)
255-626-9
Created by admin on Mon Oct 21 23:48:50 UTC 2019 , Edited by admin on Mon Oct 21 23:48:50 UTC 2019
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
Related Record Type Details
PRODRUG -> METABOLITE ACTIVE
MAJOR
PLASMA; URINE
METABOLITE -> PARENT
MINOR
URINE
METABOLITE -> PARENT
MAJOR
URINE
METABOLITE -> PARENT
MINOR
URINE
Related Record Type Details
ACTIVE MOIETY