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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H19BrN4O2.C7H8O3S
Molecular Weight 611.507
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of REMIMAZOLAM TOSYLATE

SMILES

CC1=CC=C(C=C1)S(O)(=O)=O.COC(=O)CC[C@@H]2N=C(C3=NC=CC=C3)C4=C(C=CC(Br)=C4)N5C(C)=CN=C25

InChI

InChIKey=UNLWPYSYFQLJSV-LMOVPXPDSA-N
InChI=1S/C21H19BrN4O2.C7H8O3S/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21;1-6-2-4-7(5-3-6)11(8,9)10/h3-6,8,10-12,17H,7,9H2,1-2H3;2-5H,1H3,(H,8,9,10)/t17-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C7H8O3S
Molecular Weight 172.202
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C21H19BrN4O2
Molecular Weight 439.305
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Remimazolam is an intravenous benzodiazepine sedative-hypnotic with rapid onset and offset of action. This compound undergoes organ-independent metabolism to an inactive metabolite. Like other benzodiazepines, remimazolam can be reversed with flumazenil to rapidly terminate sedation and anesthesia. Phase I and II clinical trials have shown that remimazolam is safe and effective when used for procedural sedation. Phase III clinical trials have been completed investigating efficacy and safety in patients undergoing bronchoscopy and colonoscopy. The developer of this drug has suggested that intensive care unit sedation (beyond 24 hours) could be another possible indication for further development, since it is unlikely that prolonged infusions or higher doses of remimazolam would result in accumulation and extended effect.

CNS Activity

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Substance Class Chemical
Created
by admin
on Tue Oct 22 17:04:17 UTC 2019
Edited
by admin
on Tue Oct 22 17:04:17 UTC 2019
Record UNII
9J7J08A8LT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
REMIMAZOLAM TOSYLATE
Common Name English
4H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPINE-4-PROPANOIC ACID, 8-BROMO-1-METHYL-6-(2-PYRIDINYL)-, METHYL ESTER, (4S)-, 4-METHYLBENZENESULFONATE (1:1)
Systematic Name English
METHYL (4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPINE-4-PROPANOATE 4-METHYLBENZENESULFONATE (1:1)
Systematic Name English
Code System Code Type Description
CAS
1425904-79-5
Created by admin on Tue Oct 22 17:04:17 UTC 2019 , Edited by admin on Tue Oct 22 17:04:17 UTC 2019
PRIMARY
PUBCHEM
71608022
Created by admin on Tue Oct 22 17:04:17 UTC 2019 , Edited by admin on Tue Oct 22 17:04:17 UTC 2019
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY