U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Mon Oct 21 20:18:51 UTC 2019
Edited
by admin
on Mon Oct 21 20:18:51 UTC 2019
Protein Type TRANSPORTER
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
76UB6O122H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2
Common Name English
MGC102821
Common Name English
CD338
Common Name English
BMDP
Common Name English
ABC15
Common Name English
CDW338
Common Name English
BCRP
Common Name English
BREAST CANCER RESISTANT PROTEIN
Common Name English
URATE EXPORTER
Common Name English
MXR
Common Name English
PLACENTA-SPECIFIC ATP-BINDING CASSETTE TRANSPORTER
Common Name English
MRX
Common Name English
MITOXANTRONE RESISTANCE-ASSOCIATED PROTEIN
Common Name English
EST157481
Common Name English
MXR1
Common Name English
ABCG2
Common Name English
BCRP1
Common Name English
ABCP
Common Name English
Code System Code Type Description
UCSF-FDA TRANSPORTAL
ABCG2
Created by admin on Mon Oct 21 20:18:51 UTC 2019 , Edited by admin on Mon Oct 21 20:18:51 UTC 2019
PRIMARY
CAS
479876-41-0
Created by admin on Mon Oct 21 20:18:51 UTC 2019 , Edited by admin on Mon Oct 21 20:18:51 UTC 2019
PRIMARY
CAS
481134-43-4
Created by admin on Mon Oct 21 20:18:51 UTC 2019 , Edited by admin on Mon Oct 21 20:18:51 UTC 2019
ALTERNATIVE
UNIPROT
Q9UNQ0
Created by admin on Mon Oct 21 20:18:51 UTC 2019 , Edited by admin on Mon Oct 21 20:18:51 UTC 2019
PRIMARY
CAS
481133-43-1
Created by admin on Mon Oct 21 20:18:51 UTC 2019 , Edited by admin on Mon Oct 21 20:18:51 UTC 2019
ALTERNATIVE
CAS
658014-39-2
Created by admin on Mon Oct 21 20:18:51 UTC 2019 , Edited by admin on Mon Oct 21 20:18:51 UTC 2019
ALTERNATIVE
CAS
759386-70-4
Created by admin on Mon Oct 21 20:18:51 UTC 2019 , Edited by admin on Mon Oct 21 20:18:51 UTC 2019
ALTERNATIVE
From To
1_592 1_608
2_592 2_608
3_592 3_608
4_592 4_608
1_603 2_603
3_603 4_603
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_596
N 2_596
N 3_596
N 4_596
Related Record Type Details
INHIBITOR -> TRANSPORTER
NON-SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
IC50
NON-SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
NON-INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INDUCER -> TRANSPORTER
SUBSTRATE -> TARGET
SUBSTRATE -> TRANSPORTER
NON-SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Regorafenib inhibits Pgp and BCRP in vitro.
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
MINOR
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Netupitnat: Cmax/IC50= (1-1.5μM)/6 μM = (0.167-0.25)>0.1
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Edaravone inhib it e d CYP2C9, BCRP, OAT3, and induced CYP1A2 in vitro.
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Gao et al. reported that in vitro, imatinib (1 ?M) increases the intracellular concentration of vincristine and mitoxantrone in cells overexpressing ABCB1 and ABCG2, respectively (Gao et al., 2006).
CLINICALLY SIGNIFICANT
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Terifluniomide is an inhibitor of BCRP, OAT3, OATP1B1, OCT2 in vitro
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
IC50
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
Niraparib is a substrate of P-gp and BCRP in vitro.
SUBSTRATE -> TRANSPORTER
In overexpressing BCRP and P-gp cell line, the estimate Km for both transporters is >300 ?M.
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
Tafamidis inhibits BCRP in-vitro.
IC50
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
Teriflunomide is a substrate of BCRP in vitro
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TARGET
IC50
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
inhibit 6.7% at 10 ?M
IC50
SUBSTRATE -> TRANSPORTER
Co-administration with BCRP inhibitors may increase talazoparib exposure.
SUBSTRATE -> TRANSPORTER
NON-SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INDUCER -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
LDV is a substrate for P-gp and BCRP in vitro (AD-256-2144 and AD-256-2150).
SUBSTRATE -> TRANSPORTER
NON-SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
NON-SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
The clinical relevance of these findings is unknown.
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> METABOLIC ENZYME
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL