U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H28FN3O
Molecular Weight 393.497
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LUMATEPERONE

SMILES

CN1CCN2[C@H]3CCN(CCCC(=O)C4=CC=C(F)C=C4)C[C@H]3C5=C2C1=CC=C5

InChI

InChIKey=HOIIHACBCFLJET-SFTDATJTSA-N
InChI=1S/C24H28FN3O/c1-26-14-15-28-21-11-13-27(16-20(21)19-4-2-5-22(26)24(19)28)12-3-6-23(29)17-7-9-18(25)10-8-17/h2,4-5,7-10,20-21H,3,6,11-16H2,1H3/t20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula C24H28FN3O
Molecular Weight 393.497
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Lumateperone (ITI-722/ITI-007) is a dual 5HT2A receptor antagonist/dopamine phosphoprotein modulator (DPPM) for the treatment of schizophrenia. It is an orally available compound which combines potent 5HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of dopamine receptors. Lumateperone was developed by Intra-Cellular Therapies, Inc., and is being evaluated for the treatment of schizophrenia and bipolar depression. In 3 efficacy studies in patients with acute schizophrenia, lumateperone was well-tolerated with a favorable safety profile, and in 2 studies of 3 demonstrated significantly superior efficacy over placebo.

Approval Year

PubMed

PubMed

TitleDatePubMed
Dopamine D<sub>2</sub> receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia.
2019 Feb
Patents

Patents

Substance Class Chemical
Created
by admin
on Tue Oct 22 01:30:25 UTC 2019
Edited
by admin
on Tue Oct 22 01:30:25 UTC 2019
Record UNII
70BSQ12069
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LUMATEPERONE
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
LUMATEPERONE [INN]
Common Name English
1-BUTANONE, 1-(4-FLUOROPHENYL)-4-((6BR,10AS)-2,3,6B,9,10,10A-HEXAHYDRO-3-METHYL-1H-PYRIDO(3',4':4,5)PYRROLO(1,2,3-DE)QUINOXALIN-8(7H)-YL)-
Systematic Name English
LUMATEPERONE [USAN]
Common Name English
ITI-722
Code English
LUMATEPERONE [WHO-DD]
Common Name English
ITI-007
Code English
Code System Code Type Description
ChEMBL
CHEMBL3545045
Created by admin on Tue Oct 22 01:30:25 UTC 2019 , Edited by admin on Tue Oct 22 01:30:25 UTC 2019
PRIMARY
CAS
313368-91-1
Created by admin on Tue Oct 22 01:30:25 UTC 2019 , Edited by admin on Tue Oct 22 01:30:25 UTC 2019
PRIMARY
INN
10156
Created by admin on Tue Oct 22 01:30:25 UTC 2019 , Edited by admin on Tue Oct 22 01:30:25 UTC 2019
PRIMARY
WIKIPEDIA
LUMATEPERONE
Created by admin on Tue Oct 22 01:30:25 UTC 2019 , Edited by admin on Tue Oct 22 01:30:25 UTC 2019
PRIMARY
PUBCHEM
21302490
Created by admin on Tue Oct 22 01:30:25 UTC 2019 , Edited by admin on Tue Oct 22 01:30:25 UTC 2019
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY