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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H27NO.C4H6O4
Molecular Weight 403.5118
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIPREFADOL SUCCINATE

SMILES

OC(=O)CCC(O)=O.OC1=CC=CC(=C1)[C@@]23CCCC[C@H]2CN(CC4CC4)CC3

InChI

InChIKey=RAGPBJMJHPNLAJ-QQTWVUFVSA-N
InChI=1S/C19H27NO.C4H6O4/c21-18-6-3-5-16(12-18)19-9-2-1-4-17(19)14-20(11-10-19)13-15-7-8-15;5-3(6)1-2-4(7)8/h3,5-6,12,15,17,21H,1-2,4,7-11,13-14H2;1-2H2,(H,5,6)(H,7,8)/t17-,19-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C4H6O4
Molecular Weight 118.088
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C19H27NO
Molecular Weight 285.4238
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Ciprefadol is an opioid analgesic drug. It binds with a high affinity to mu (Ki 4.2 nM) and kappa (Ki 2.5 nM) opioid receptors. In vivo, ciprefadol displays mixed antagonist/agonist activity in the mouse writhing and the rat tail heat tests: in low doses, the compound inhibits the analgesic effect of morphine, while at higher doses it displays analgesic effect. Chronic administration of ciprefadol to rhesus monkeys produced a marked physical dependence more severe than that of morphine, and its effect was consistent with what would be expected of a potent, long-lasting morphine-like agonist.

Approval Year

Substance Class Chemical
Created
by admin
on Tue Oct 22 06:06:25 UTC 2019
Edited
by admin
on Tue Oct 22 06:06:25 UTC 2019
Record UNII
68ENP3YGUF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIPREFADOL SUCCINATE
USAN  
USAN  
Official Name English
CIPREFADOL SUCCINATE [USAN]
Common Name English
(-)-M-(2-(CYCLOPROPYLMETHYL)-1,3,4,5,6,7,8,8A.ALPHA.-OCTAHYDRO-4A.BETA.(2H)-ISOQUINOLYL)PHENOL SUCCINATE (1:1) (SALT)
Common Name English
COMPOUND 113878
Code English
PHENOL, 3-(2-(CYCLOPROPYLMETHYL)OCTAHYDRO-4A(2H)-ISOQUINOLINYL-, TRANS, (-)-, BUTANEDIOATE (1:1) (SALT)
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C241
Created by admin on Tue Oct 22 06:06:25 UTC 2019 , Edited by admin on Tue Oct 22 06:06:25 UTC 2019
Code System Code Type Description
EPA CompTox
60719-85-9
Created by admin on Tue Oct 22 06:06:25 UTC 2019 , Edited by admin on Tue Oct 22 06:06:25 UTC 2019
PRIMARY
PUBCHEM
333482
Created by admin on Tue Oct 22 06:06:25 UTC 2019 , Edited by admin on Tue Oct 22 06:06:25 UTC 2019
PRIMARY
NCI_THESAURUS
C79934
Created by admin on Tue Oct 22 06:06:25 UTC 2019 , Edited by admin on Tue Oct 22 06:06:25 UTC 2019
PRIMARY
CAS
60719-85-9
Created by admin on Tue Oct 22 06:06:25 UTC 2019 , Edited by admin on Tue Oct 22 06:06:25 UTC 2019
PRIMARY
ChEMBL
CHEMBL2111073
Created by admin on Tue Oct 22 06:06:25 UTC 2019 , Edited by admin on Tue Oct 22 06:06:25 UTC 2019
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY