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Details

Stereochemistry ACHIRAL
Molecular Formula C25H26N6O
Molecular Weight 426.5135
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PRATOSARTAN

SMILES

CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)C(=O)CCCC2

InChI

InChIKey=KCTFTBCZZUBAKN-UHFFFAOYSA-N
InChI=1S/C25H26N6O/c1-2-7-23-26-21-10-5-6-11-22(32)24(21)31(23)16-17-12-14-18(15-13-17)19-8-3-4-9-20(19)25-27-29-30-28-25/h3-4,8-9,12-15H,2,5-7,10-11,16H2,1H3,(H,27,28,29,30)

HIDE SMILES / InChI

Molecular Formula C25H26N6O
Molecular Weight 426.5135
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pratosartan is an orally active angiotensin II type 1 receptor blocker. It is being developed for the treatment of hypertension. Pratosartan was efficacious throughout the long-term study, without serious adverse effects. Pratosartan significantly decreased serum total cholesterol in patients with hypercholesterolemia and uric acid in patients with hyperuricemia. It may have beneficial effects on hypertensive patients with some metabolic disorders. Pratosartan is still in phase III development in South Korea and phase II in Japan for hypertension.

Approval Year

PubMed

PubMed

TitleDatePubMed
Antihypertensive effect of chronic KT3-671, a structurally new nonpeptide angiotensin AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats.
1995 Nov
Synthesis and pharmacological activity of the metabolites of Pratosartan.
2006 Jun
Regioselective alkylation of 2-alkyl-5,6,7,8-tetrahydro-3h-cycloheptimidazol-4-ones and 2-alkyl-3h-cycloheptimidazol-4-ones.
2006 May
Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter.
2007 Jan
Effects of angiotensin II receptor blockers on renal handling of uric acid in rats.
2008
Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients.
2008 Feb
Gateways to clinical trials. July-August 2008.
2008 Jul-Aug
Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers.
2008 Mar
Patents
Substance Class Chemical
Created
by admin
on Mon Oct 21 23:44:19 UTC 2019
Edited
by admin
on Mon Oct 21 23:44:19 UTC 2019
Record UNII
66VLQ6E6DL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PRATOSARTAN
INN   JAN   WHO-DD  
INN  
Official Name English
KT3-671
Code English
PRATOSARTAN [INN]
Common Name English
PRATOSARTAN [WHO-DD]
Common Name English
PRATOSARTAN [JAN]
Common Name English
DA-727
Code English
Classification Tree Code System Code
NCI_THESAURUS C66930
Created by admin on Mon Oct 21 23:44:19 UTC 2019 , Edited by admin on Mon Oct 21 23:44:19 UTC 2019
Code System Code Type Description
CAS
153804-05-8
Created by admin on Mon Oct 21 23:44:19 UTC 2019 , Edited by admin on Mon Oct 21 23:44:19 UTC 2019
PRIMARY
MESH
C528642
Created by admin on Mon Oct 21 23:44:19 UTC 2019 , Edited by admin on Mon Oct 21 23:44:19 UTC 2019
PRIMARY
ChEMBL
CHEMBL41194
Created by admin on Mon Oct 21 23:44:19 UTC 2019 , Edited by admin on Mon Oct 21 23:44:19 UTC 2019
PRIMARY
INN
8100
Created by admin on Mon Oct 21 23:44:19 UTC 2019 , Edited by admin on Mon Oct 21 23:44:19 UTC 2019
PRIMARY
PUBCHEM
9802561
Created by admin on Mon Oct 21 23:44:19 UTC 2019 , Edited by admin on Mon Oct 21 23:44:19 UTC 2019
PRIMARY
NCI_THESAURUS
C72935
Created by admin on Mon Oct 21 23:44:19 UTC 2019 , Edited by admin on Mon Oct 21 23:44:19 UTC 2019
PRIMARY
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ACTIVE MOIETY