U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14N5O8P
Molecular Weight 363.221
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FOSDENOPTERIN

SMILES

C1[C@]2([H])[C@@]([H])(C([C@@]3([H])[C@]([H])(Nc4c(c(nc(=N)[nH]4)O)N3)O2)(O)O)OP(=O)(O)O1

InChI

InChIKey=CZAKJJUNKNPTTO-AJFJRRQVSA-N
InChI=1S/C10H14N5O8P/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16)/t2-,4-,5+,8-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H14N5O8P
Molecular Weight 363.221
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Cyclic pyranopterin monophosphate is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase/oxidase, and aldehyde oxidase. The drug is being investigated in severe molybdenum cofactor deficiency type A. In a clinical study, intravenous administration of the drug resulted in greatly improved neurodevelopmental outcome when started sufficiently early.

Approval Year

Substance Class Chemical
Created
by admin
on Sat Jun 26 08:52:26 UTC 2021
Edited
by admin
on Sat Jun 26 08:52:26 UTC 2021
Record UNII
4X7K2681Y7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYCLIC PYRANOPTERIN MONOPHOSPHATE
Preferred Name English
FOSDENOPTERIN
INN   USAN  
Official Name English
ALXN-1101 ANHYDROUS FREE BASE
Code English
PRECURSOR Z
Common Name English
C(PMP)
Common Name English
1,3,2-DIOXAPHOSPHORINO(4',5':5,6)PYRANO(3,2-G)PTERIDIN-10(4H)-ONE, 8-AMINO-4A,5A,6,7,11,11A,12,12A-OCTAHYDRO-2,12,12-TRIHYDROXY-, 2-OXIDE, (4AR,5AR,11AR,12AS)-
Common Name English
CPMP
Common Name English
FOSDENOPTERIN [INN]
Common Name English
FOSDENOPTERIN [USAN COUN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 291209
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
EU-Orphan Drug EU/3/10/777
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
Code System Code Type Description
CAS
150829-29-1
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
EVMPD
SUB197148
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
NCI_THESAURUS
C175065
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
WIKIPEDIA
Cyclic pyranopterin monophosphate
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
FDA UNII
4X7K2681Y7
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
INN
11150
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
PUBCHEM
135463437
Created by admin on Sat Jun 26 08:52:27 UTC 2021 , Edited by admin on Sat Jun 26 08:52:27 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY