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Details

Stereochemistry ACHIRAL
Molecular Formula C8H9NO2
Molecular Weight 151.1626
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of O-HYDROXYACETANILIDE

SMILES

CC(=O)NC1=CC=CC=C1O

InChI

InChIKey=ADVGKWPZRIDURE-UHFFFAOYSA-N
InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)

HIDE SMILES / InChI

Molecular Formula C8H9NO2
Molecular Weight 151.1626
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

O-Hydroxyacetanilide or N-(2-hydroxyphenyl)acetamide is a derivative of salicylic acid exerting anti-inflammatory activity. It ameliorated the severity of adjuvant-induced arthritis in rats.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PubMed

PubMed

TitleDatePubMed
Microbial conversion of acetanilide to 2'-hydroxyacetanilide and 4'-hydroxyacetanilide.
1967 Nov
Acetanilide 4-hydroxylase and acetanilide 2-hydroxylase activity in hepatic microsomes from induced mice.
1991 Feb
N-(2-hydroxy phenyl) acetamide inhibits inflammation-related cytokines and ROS in adjuvant-induced arthritic (AIA) rats.
2010 Aug
N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-Fos protein and mRNA expression in the brain of adjuvant-induced arthritic rats.
2014 Feb

Sample Use Guides

In Vivo Use Guide
rats: 5 or 10 mg/kg
Route of Administration: Intraperitoneal
Substance Class Chemical
Created
by admin
on Tue Oct 22 06:41:22 UTC 2019
Edited
by admin
on Tue Oct 22 06:41:22 UTC 2019
Record UNII
4AS8989RNI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
O-HYDROXYACETANILIDE
Common Name English
N-ACETYL-O-AMINOPHENOL
Systematic Name English
HYDROXYACETANILIDE, O-
Common Name English
O-ACETAMINOPHENOL
Systematic Name English
NSC-3989
Code English
2-HYDROXYACETANILIDE
Systematic Name English
ACETANILIDE, 2'-HYDROXY-
Systematic Name English
2-(N-ACETYLAMINO)PHENOL
Systematic Name English
O-ACETAMIDOPHENOL
Systematic Name English
2-ACETAMIDOPHENOL
Systematic Name English
PARACETAMOL IMPURITY A [EP]
Common Name English
ACETAMINOPHEN RELATED COMPOUND C [USP-RS]
Common Name English
O-(ACETYLAMINO)PHENOL
Systematic Name English
ACETAMIDE, N-(2-HYDROXYPHENYL)-
Systematic Name English
2'-HYDROXYACETANILIDE
Systematic Name English
N-ACETYL-2-AMINOPHENOL
Systematic Name English
N-(2-HYDROXYPHENYL)ACETAMIDE
Systematic Name English
ACETAMINOPHEN RELATED COMPOUND C [USP]
USP-RS  
Common Name English
ACETANILIDE, O-HYDROXY-
Systematic Name English
2-(ACETYLAMINO)PHENOL
Systematic Name English
2-ACETAMINOPHENOL
Systematic Name English
Code System Code Type Description
EPA CompTox
614-80-2
Created by admin on Tue Oct 22 06:41:22 UTC 2019 , Edited by admin on Tue Oct 22 06:41:22 UTC 2019
PRIMARY
ECHA (EC/EINECS)
210-396-9
Created by admin on Tue Oct 22 06:41:22 UTC 2019 , Edited by admin on Tue Oct 22 06:41:22 UTC 2019
PRIMARY
PUBCHEM
11972
Created by admin on Tue Oct 22 06:41:22 UTC 2019 , Edited by admin on Tue Oct 22 06:41:22 UTC 2019
PRIMARY
CAS
614-80-2
Created by admin on Tue Oct 22 06:41:22 UTC 2019 , Edited by admin on Tue Oct 22 06:41:22 UTC 2019
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP