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Details

Stereochemistry ACHIRAL
Molecular Formula C4H10N2O
Molecular Weight 102.135
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-NITROSODIETHYLAMINE

SMILES

CCN(CC)N=O

InChI

InChIKey=WBNQDOYYEUMPFS-UHFFFAOYSA-N
InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C4H10N2O
Molecular Weight 102.135
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase.
2001
Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats.
2001
Effects of griseofulvin in medium-term liver carcinogenesis assay and peripheral blood micronucleus test in rat.
2001
Nuclear Ras: unexpected subcellular distribution of oncogenic forms.
2001
Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver.
2001
Genotoxic effects of N-nitrosodicyclohexylamine in isolated human lymphocytes.
2001 Apr
Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.
2001 Apr
Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios.
2001 Aug
Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.
2001 Aug
Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis.
2001 Aug
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.
2001 Aug 15
Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis.
2001 Aug 16
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
2001 Dec
Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats.
2001 Dec
Anticarcinogenic effect of red ginseng on the development of liver cancer induced by diethylnitrosamine in rats.
2001 Dec
Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats.
2001 Jan
Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats.
2001 Jul
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
2001 Jun
Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice.
2001 Jun 2
Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies.
2001 Jun 2
Liposome encapsulated tumor-associated antigens elicited humoral and cellular immune responses in mice bearing tumor.
2001 Mar
Bioassay of mannitol and caprolactam and assessment of response to diethylnitrosamine in heterozygous p53-deficient (+/-) and wild type (+/+) mice.
2001 Mar
Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma.
2001 Mar
Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin.
2001 Mar
1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis.
2001 Mar 26
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity.
2001 Mar 31
Specific genomic alterations in rat renal cell carcinomas induced by N-ethyl-N-hydroxyethylnitrosamine.
2001 Mar-Apr
Inhibition of chemical carcinogenesis by berberine in rats and mice.
2001 May
Expression profiling and identification of novel genes in hepatocellular carcinomas.
2001 May 10
Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced tumor promotion by 17 beta-estradiol in female Sprague--Dawley rats.
2001 May 15
Genotoxicity of nitroso compounds and sodium dichromate in a model combining organ cultures of human nasal epithelia and the comet assay.
2001 May-Jun
The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses.
2001 Nov
Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model.
2001 Nov
Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis.
2001 Nov
The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility.
2001 Nov
The importance of distinct metabolites of N-nitrosodiethylamine for its in vivo mutagenic specificity.
2001 Nov 1
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase.
2001 Nov 1
Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors.
2001 Nov 22
[Genetic control of hepatocarcinogenesis in mice].
2001 Oct
Immunohistochemical characterization of hepatoblastomas in B6C3F1 mice treated with diethylnitrosamine and sodium phenobarbital.
2001 Oct
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
2001 Oct
Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia.
2001 Oct
Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis.
2001 Oct
Inheritance of resistance to promotion of preneoplastic liver lesions in Copenhagen rats.
2001 Oct
Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat.
2001 Sep
Matrix metalloproteinases-2 and 9 do not play a role in the growth of preneoplastic liver lesions in F344 rats.
2001 Sep
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
2001 Sep 15
Strain variation in renal carcinogenesis by N-ethyl-N-hydroxyethylnitrosamine in F1 (Wistar-Fischer) rats.
2001 Sep 20
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.
2001 Sep-Oct
Summation of initiation activities in the liver after partial hepatectomy.
2002 Feb 8
Substance Class Chemical
Created
by admin
on Mon Oct 21 21:20:51 UTC 2019
Edited
by admin
on Mon Oct 21 21:20:51 UTC 2019
Record UNII
3IQ78TTX1A
Record Status Validated (UNII)
Record Version
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Name Type Language
N-NITROSODIETHYLAMINE
HSDB   MI  
Systematic Name English
DENA
Common Name English
DIETHYLAMINE, N-NITROSO-
Systematic Name English
N-NITROSODIETHYLAMINE [HSDB]
Common Name English
DEN
Common Name English
NSC-132
Code English
N-NITROSODIETHYLAMINE [IARC]
Common Name English
NDEA
Common Name English
N-NITROSODIETHYLAMINE [MI]
Common Name English
ETHANAMINE, N-ETHYL-N-NITROSO-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C45398
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
IARC <i>N</i>-Nitrosodiethylamine
Code System Code Type Description
ECHA (EC/EINECS)
200-226-1
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY
NCI_THESAURUS
C29827
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY
CAS
55-18-5
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY
PUBCHEM
5921
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY
HSDB
55-18-5
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY
EPA CompTox
55-18-5
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY
MERCK INDEX
M7993
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY Merck Index
WIKIPEDIA
N-Nitrosodiethylamine
Created by admin on Mon Oct 21 21:20:51 UTC 2019 , Edited by admin on Mon Oct 21 21:20:51 UTC 2019
PRIMARY
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