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Details

Stereochemistry ACHIRAL
Molecular Formula C29H34Cl2N6O3S2
Molecular Weight 649.655
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AVATROMBOPAG

SMILES

OC(=O)C1CCN(CC1)C2=NC=C(C=C2Cl)C(=O)NC3=NC(C4=CC(Cl)=CS4)=C(S3)N5CCN(CC5)C6CCCCC6

InChI

InChIKey=OFZJKCQENFPZBH-UHFFFAOYSA-N
InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)

HIDE SMILES / InChI

Molecular Formula C29H34Cl2N6O3S2
Molecular Weight 649.655
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PMID

PMID

TitleDatePMID
AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis.
2008 Oct
AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.
2009 Apr
Romiplostim: a second-generation thrombopoietin agonist.
2009 Mar
Patent

Patent

Substance Class Chemical
Created
by admin
on Tue Mar 06 11:29:49 UTC 2018
Edited
by admin
on Tue Mar 06 11:29:49 UTC 2018
Record UNII
3H8GSZ4SQL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AVATROMBOPAG
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
AVATROMBOPAG [INN]
Common Name English
AVATROMBOPAG [WHO-DD]
Common Name English
AKR-501
Common Name English
YM-477
Code English
AVATROMBOPAG [USAN]
Common Name English
E5501
Code English
E-5501
Code English
E 5501
Common Name English
1-(3-CHLORO-5-((4-(4-CHLOROTHIOPHEN-2-YL)-5-(4-CYCLOHEXYLPIPERAZIN-1-YL)THIAZOL-2-YL)CARBAMOYL)PYRIDIN-2-YL)PIPERIDINE-4-CARBOXYLIC ACID
Systematic Name English
1-(3-CHLORO-5-((4-(4-CHLOROTHIOPHEN-2-YL)-5-(4-CYCLOHEXYLPIPERAZIN-1-YL)THIAZOL-2-YL)CARBAMOYL)-2-PYRIDYL)PIPERIDINE-4-CARBOXYLIC ACID
Systematic Name English
Code System Code Type Description
PUBCHEM
9852519
Created by admin on Tue Mar 06 11:29:49 UTC 2018 , Edited by admin on Tue Mar 06 11:29:49 UTC 2018
PRIMARY
INN
9571
Created by admin on Tue Mar 06 11:29:49 UTC 2018 , Edited by admin on Tue Mar 06 11:29:49 UTC 2018
PRIMARY
CAS
570406-98-3
Created by admin on Tue Mar 06 11:29:49 UTC 2018 , Edited by admin on Tue Mar 06 11:29:49 UTC 2018
PRIMARY
EVMPD
SUB121659
Created by admin on Tue Mar 06 11:29:49 UTC 2018 , Edited by admin on Tue Mar 06 11:29:49 UTC 2018
PRIMARY
EPA CompTox
570406-98-3
Created by admin on Tue Mar 06 11:29:49 UTC 2018 , Edited by admin on Tue Mar 06 11:29:49 UTC 2018
PRIMARY
ChEMBL
CHEMBL2103883
Created by admin on Tue Mar 06 11:29:49 UTC 2018 , Edited by admin on Tue Mar 06 11:29:49 UTC 2018
PRIMARY
Related Record Type Details
TARGET->IMAGING AGENT
Related Record Type Details
ACTIVE MOIETY