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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H31NO3
Molecular Weight 393.5195
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HT-0712

SMILES

Cc1cccc(c1)C[C@]2([H])C[C@]([H])(CN=C2O)c3ccc(c(c3)OC4CCCC4)OC

InChI

InChIKey=ABEJDMOBAFLQNJ-NHCUHLMSSA-N
InChI=1S/C25H31NO3/c1-17-6-5-7-18(12-17)13-20-14-21(16-26-25(20)27)19-10-11-23(28-2)24(15-19)29-22-8-3-4-9-22/h5-7,10-12,15,20-22H,3-4,8-9,13-14,16H2,1-2H3,(H,26,27)/t20-,21-/m1/s1

HIDE SMILES / InChI

Molecular Formula C25H31NO3
Molecular Weight 393.5195
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Inflazyme Pharmaceuticals initially developed HT-0712 as a phosphodiesterase IV (PDE4) inhibitor with anti-inflammatory properties. Now the rights on this drug are wholly owned by Dart NeuroScience. January 2015, Dart NeuroScience completed a phase II trial of HT-0712 for the memory disorders, where were evaluated the efficacy in improving memory and cognitive performance.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4.
2003 Sep 2
A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia.
2007 Nov-Dec
Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?
2008 Oct
The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice.
2014 Dec
Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease.
2017 Sep

Sample Use Guides

HT-0712 capsules (50mg) administered once daily.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 16:40:11 UTC 2021
Edited
by admin
on Sat Jun 26 16:40:11 UTC 2021
Record UNII
2O43FXG9IG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HT-0712
Common Name English
OX-914
Code English
BLX-028914
Code English
IPL-455903
Code English
2-PIPERIDINONE, 5-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)-3-((3-METHYLPHENYL)METHYL)-, (3S,5S)-
Systematic Name English
Code System Code Type Description
WIKIPEDIA
HT-0712
Created by admin on Sat Jun 26 16:40:11 UTC 2021 , Edited by admin on Sat Jun 26 16:40:11 UTC 2021
PRIMARY
FDA UNII
2O43FXG9IG
Created by admin on Sat Jun 26 16:40:11 UTC 2021 , Edited by admin on Sat Jun 26 16:40:11 UTC 2021
PRIMARY
CAS
617720-02-2
Created by admin on Sat Jun 26 16:40:11 UTC 2021 , Edited by admin on Sat Jun 26 16:40:11 UTC 2021
PRIMARY
DRUG BANK
DB11650
Created by admin on Sat Jun 26 16:40:11 UTC 2021 , Edited by admin on Sat Jun 26 16:40:11 UTC 2021
PRIMARY
PUBCHEM
9865375
Created by admin on Sat Jun 26 16:40:11 UTC 2021 , Edited by admin on Sat Jun 26 16:40:11 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY