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Details

Stereochemistry ACHIRAL
Molecular Formula C15H23ClN4O2.C4H6O4
Molecular Weight 444.91
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAZOPRIDE SUCCINATE

SMILES

OC(=O)CCC(O)=O.CCN1CC(CN1CC)NC(=O)C2=CC(Cl)=C(N)C=C2OC

InChI

InChIKey=HLDCRAZAHFKARV-UHFFFAOYSA-N
InChI=1S/C15H23ClN4O2.C4H6O4/c1-4-19-8-10(9-20(19)5-2)18-15(21)11-6-12(16)13(17)7-14(11)22-3;5-3(6)1-2-4(7)8/h6-7,10H,4-5,8-9,17H2,1-3H3,(H,18,21);1-2H2,(H,5,6)(H,7,8)

HIDE SMILES / InChI

Molecular Formula C4H6O4
Molecular Weight 118.088
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C15H23ClN4O2
Molecular Weight 326.822
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dazopride is an antagonist of the 5-HT3 receptor and agonist of the 5-HT4 receptor, structurally related to metoclopramide. Dazopride was developed by A. H. Robins Company as an antiemetic and gastroprokinetic drug. Dazoptide demonstrated an antiemetic effect in the clinic after i.v. infusion to patients, receiving anticancer therapy.

Approval Year

Patents

Patents

Sample Use Guides

In Vivo Use Guide
i.v. infusions every 2 h beginning 30 min before the chemotherapy at doses 0.5 to 4.0 mg/kg.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Tue Oct 22 09:13:51 UTC 2019
Edited
by admin
on Tue Oct 22 09:13:51 UTC 2019
Record UNII
25S5HB67BK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DAZOPRIDE SUCCINATE
Common Name English
BUTANEDIOIC ACID, COMPD. WITH 4-AMINO-5-CHLORO-N-(1,2-DIETHYL-4-PYRAZOLIDINYL)-2-METHOXYBENZAMIDE (1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
6917727
Created by admin on Tue Oct 22 09:13:51 UTC 2019 , Edited by admin on Tue Oct 22 09:13:51 UTC 2019
PRIMARY
CAS
100981-14-4
Created by admin on Tue Oct 22 09:13:51 UTC 2019 , Edited by admin on Tue Oct 22 09:13:51 UTC 2019
NON-SPECIFIC STOICHIOMETRY
CAS
106613-26-7
Created by admin on Tue Oct 22 09:13:51 UTC 2019 , Edited by admin on Tue Oct 22 09:13:51 UTC 2019
PRIMARY
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ACTIVE MOIETY