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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H24O11.2H2O
Molecular Weight 380.3429
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LACTITOL DIHYDRATE

SMILES

O.O.OC[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO

InChI

InChIKey=VAOUPFUEMFJHKI-MTURKXFLSA-N
InChI=1S/C12H24O11.2H2O/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12;;/h4-21H,1-3H2;2*1H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula C12H24O11
Molecular Weight 344.3124
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 9 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Lactitol is a sugar alcohol. This ingredient has been determined to be GRAS for specified uses as a direct food additive and foods containing lactitol are eligible for a health claim related to dental caries. Lactitol is used as an oral powder or solution in the management of hepatic encephalopathy and in case of short-term treatment of occasional constipation. Intestinal flora of large intestine is metabolize lactitol to low-molecular organic acid, which leads to an increase in osmotic pressure in intestine, increase in volume of fecal masses bowel function normalization. This drug might cause abdominal discomfort, especially flatulence and abdominal pain rarely or sometimes abdominal distension. These effects tend to diminish or disappear after a few days of regular intake of the drug. Since 'antacids and neomycin can neutralize ' acidifying effect of lactitol on stool, they should not be co-administered with lactitol in cirrhotic patients with hepatic encephalopathy; however both substances do not alter the 'laxative effect in patients with constipation.

Originator

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Importal
Primary
Importal
PubMed

PubMed

TitleDatePubMed
Structural changes in natural actomyosin and surimi from ling cod (Ophiodon elongatus) during frozen storage in the absence or presence of cryoprotectants.
2001 Oct
Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro.
2002 Jun
Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs.
2002 Mar
Cyclic treatment of chronic hepatic encephalopathy with rifaximin. Results of a double-blind clinical study.
2003 Mar
Chemoenzymatically synthesized glycoconjugate polymers.
2003 Mar-Apr
Nonabsorbable disaccharides for hepatic encephalopathy.
2004
Review: lactulose or lactitol may improve hepatic encephalopathy but may be less effective than antibiotics.
2004 Nov-Dec
Comparison of rifaximin and lactulose for the treatment of hepatic encephalopathy: a prospective randomized study.
2005 Jun 30
[Pneumatosis intestinalis in 9 children with an oncologic disease].
2005 Mar 19
Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar.
2005 Oct
[Intestinal function tests].
2005 Sep 14
Management of hepatic encephalopathy: focus on antibiotic therapy.
2006
Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium.
2006 Apr
Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis.
2007 Jan
Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis.
2008
[Influence of the bifidobacteria and lactitol containing products on lypoperoxidation processes and intestinal microflora].
2008
Rifaximin for the treatment of hepatic encephalopathy.
2008 Aug
Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, double-blind, randomized, placebo-controlled study.
2008 Jan 15
Xylitol-supplemented nutrition enhances bacterial killing and prolongs survival of rats in experimental pneumococcal sepsis.
2008 Mar 11
Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence.
2008 May
[Prebiotic lactitol as a component of biopreparation from aerobic bacilli].
2008 Nov-Dec
Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days.
2009
Sugar alcohols, caries incidence, and remineralization of caries lesions: a literature review.
2010
Idiopathic proximal hemimegacolon in an adult woman.
2010 Apr
Successful drug development despite adverse preclinical findings part 2: examples.
2010 Dec
Microbial and bioconversion production of D-xylitol and its detection and application.
2010 Dec 15
Standards of medical care in diabetes--2010.
2010 Jan
Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures.
2010 Jun
Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model.
2010 Jun
Recombinant human granulocyte colony stimulating factor pre-screening and screening of stabilizing carbohydrates and polyols.
2010 Mar 15
Lactitol or lactulose in the treatment of chronic constipation: result of a systematic.
2010 Nov
Current and emerging strategies for treating hepatic encephalopathy.
2010 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Initial dose - 20 g at once during 4-5 days. Next, 10 g per day.
Route of Administration: Oral
In Vitro Use Guide
The species of bifidobacteria, which were detected in vessel of each fermentation after adaptation to an Lactitol 1% (wt/vol): Bifidobacterium adolescentis, B. bifidum, B. longum, B. dentium and B. catenulatum. B. angulatum, B. breve and B. infantis were not detected.
Substance Class Chemical
Created
by admin
on Tue Oct 22 12:48:37 UTC 2019
Edited
by admin
on Tue Oct 22 12:48:37 UTC 2019
Record UNII
1F5S85F60B
Record Status Validated (UNII)
Record Version
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Name Type Language
LACTITOL DIHYDRATE
MI  
Common Name English
LACTOSITOL DIHYDRATE
Common Name English
LACTITOL DIHYDRATE [MI]
Common Name English
D-GLUCITOL, 4-O-.BETA.-D-GALACTOPYRANOSYL-, DIHYDRATE
Common Name English
Code System Code Type Description
PUBCHEM
157354
Created by admin on Tue Oct 22 12:48:37 UTC 2019 , Edited by admin on Tue Oct 22 12:48:37 UTC 2019
PRIMARY
EPA CompTox
81025-03-8
Created by admin on Tue Oct 22 12:48:37 UTC 2019 , Edited by admin on Tue Oct 22 12:48:37 UTC 2019
PRIMARY
MERCK INDEX
M6659
Created by admin on Tue Oct 22 12:48:37 UTC 2019 , Edited by admin on Tue Oct 22 12:48:37 UTC 2019
PRIMARY Merck Index
CAS
81025-03-8
Created by admin on Tue Oct 22 12:48:37 UTC 2019 , Edited by admin on Tue Oct 22 12:48:37 UTC 2019
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE