U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H8ClN3O4S2
Molecular Weight 297.739
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROCHLOROTHIAZIDE

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1

InChI

InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N
InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

HIDE SMILES / InChI

Molecular Formula C7H8ClN3O4S2
Molecular Weight 297.739
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

CAPOZIDE (captopril and hydrochlorothiazide tablets, USP) for oral administration combines two antihypertensive agents: captopril and hydrochlorothiazide. The mechanism of action of captopril has not yet been fully elucidated. Captopril prevents the conversion of angiotensin I to angiotensin II by inhibition of ACE, a peptidyldipeptide carboxy hydrolase. Hydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na+) reabsorption in the distal convoluted tubule. CAPOZIDE (captopril and hydrochlorothiazide tablets, USP) is indicated for the treatment of hypertension. The blood pressure lowering effects of captopril and thiazides are approximately additive. Major side effects are: Black, tarry stools; chest pain; chills; cough; fever; painful or difficult urination; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; unusual bleeding or bruising; unusual tiredness or weakness. It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension. Captopril’s effect will be augmented by antihypertensive agents that cause renin release. For example, diuretics (e.g., thiazides) may activate the renin-angiotensin-aldosterone system.

CNS Activity

Approval Year

PubMed

PubMed

TitleDatePubMed
Captopril and hydrochlorothiazide combined: Acezide/Capozide.
1989 Jul 24
Captopril versus captopril plus hydrochlorothiazide for essential hypertension in Koreans.
1991 Jan 1
Captopril and hydrochlorothiazide (Capozide) combine to enhance the reduction in voluntary alcohol intake in rats.
1993 Oct
[Capozide-50 alone and in combination with melatonin in therapy of hypertension].
2000
Patents

Sample Use Guides

In Vivo Use Guide
therapy may be instituted with a single tablet of CAPOZIDE (captopril/hydrochlorothiazide) 25 mg/15 mg taken once daily. For patients insufficiently responsive to the initial dose, additional captopril or hydrochlorothiazide may be added as individual components or by using CAPOZIDE (captopril/hydrochlorothiazide) 50 mg/15 mg, 25 mg/25 mg or 50 mg/25 mg, or divided doses may be used. Daily doses of captopril should not exceed 150 mg and of hydrochlorothiazide should not exceed 50 mg.
Route of Administration: Oral
In Vitro Use Guide
In the presence of captopril (2 X 10^4 M), contractile responses to angiotensln I (5 X 10^10 to 5 X 10^8 M) were attenuated significantly.
Substance Class Chemical
Created
by admin
on Mon Oct 21 20:42:24 UTC 2019
Edited
by admin
on Mon Oct 21 20:42:24 UTC 2019
Record UNII
0J48LPH2TH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROCHLOROTHIAZIDE
EMA EPAR   EP   GREEN BOOK   HSDB   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
ORETICYL FORTE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE [IARC]
Common Name English
SER-A-GEN COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
SU-5879
Code English
CAROZIDE
Common Name English
UNIPRES COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
ZIAC
Brand Name English
HYDRO-D
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF H.R.-50
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF MAXZIDE
Common Name English
NSC-53477
Code English
MICROZIDE
Brand Name English
ZIDE
Brand Name English
HYDROCHLOROTHIAZIDE [USP]
Common Name English
IMPRIDA-HCT
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF DUTOPROL
Common Name English
HYDRO-RESERP COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF ESIMIL
Common Name English
HYDROCHLOROTHIAZIDE [ORANGE BOOK]
Common Name English
ALDACTAZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF CAM-AP-ES
Common Name English
IDROTIAZIDE
Brand Name English
PANTEMON
Brand Name English
DAFIRO-HCT
Brand Name English
HYDROCHLOROTHIAZIDE [USP-RS]
Common Name English
SERPASIL-ESIDRIX COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
IFIRMACOMBI COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF IRBESARTAN/HYDROCHLOROTHIAZIDE TEVA
Brand Name English
ZIAC COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF LOTENSIN HCT
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF DYAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYDRO-RIDE
Common Name English
HYDROCHLOROTHIAZIDE [WHO-DD]
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF RASILEZ-HCT
Brand Name English
KINZALKOMB COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
AVALIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
PRITORPLUS COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
MODURETIC COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF UNIPRES
Common Name English
TRIBENZOR COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
HYDRODIURIL
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF SERPASIL-ESIDRIX
Common Name English
HYDROCHLOROTHIAZIDE [MART.]
Common Name English
ORETIC
Brand Name English
ESIDREX
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT
Brand Name English
TEKTURNA HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
6-CHLORO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
Systematic Name English
RIPRAZO COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
SERVITHIAZID
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF UNIRETIC
Common Name English
HYDROCHLOROTHIAZIDE [GREEN BOOK]
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF ALDORIL
Common Name English
HYDROCHLOROTHIAZIDE [WHO-IP]
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF KINZALKOMB
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF AMTURNIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF SER-A-GEN
Common Name English
AMTURNIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF ORETICYL FORTE
Common Name English
HYDROCHLOROTHIAZIDE [EP]
Common Name English
HYDROCHLOROTHIAIZIDE
Brand Name English
HYDRAP-ES COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDRALAZINE HYDROCHLORIDE-HYDROCHLOROTHIAZIDE-RESERPINE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
LOTENSIN HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
NORMOZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF IFIRMACOMBI
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF IRBESARTAN/HYDROCHLOROTHIAZIDE-BMS
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF LOPRESSOR HCT
Common Name English
BENICAR HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HCTZ
Common Name English
VASERETIC COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
MEGADIURIL
Common Name English
VISKAZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
DYAZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
APRESOLINE-ESIDRIX COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE [INN]
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF MICARDISPLUS
Brand Name English
CHLOROSULTHIADIL
Common Name English
MONOPRIL HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
SPRIMEO-HCT COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
HYDROCHLOROTHIAZDE COMPONENT OF TOULOMI
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF TRIBENZOR
Brand Name English
IBERSARTAN/HYDROCHLOROTHIAZIDE ZENTIVA COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
HYDROCHLOROTHIAZIDE [VANDF]
Common Name English
HYDROCHLOROTHIAZIDE [MI]
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF RASITRIO
Brand Name English
HYDRA-ZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF TEVETEN HCT
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYDROSERPINE PLUS (R-H-H)
Common Name English
ESIDRIX
Brand Name English
RASITRIO COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
HYZAAR COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF ZESTORETIC
Common Name English
TEVETEN HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
CAM-AP-ES COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
MAXZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF IBERSARTAN/HYDROCHLOROTHIAZIDE ZENTIVA
Brand Name English
ESIMIL COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF AVALIDE
Common Name English
SER-AP-ES COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYDRO-RESERP
Common Name English
QUINARETIC COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYDRA-ZIDE
Common Name English
2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3,4-DIHYDRO-, 1,1-DIOXIDE
Systematic Name English
DUTOPROL COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF VASERETIC
Common Name English
RASILEZ-HCT
Brand Name English
VETIDREX
Brand Name English
POLYCAP COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF QUINARETIC
Common Name English
UNIPRES
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYZAAR
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF NORMOZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF BENICAR HCT
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF APRESAZIDE
Common Name English
KERVEZIDE COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
MICARDIS HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
LOPRESSOR HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE [HSDB]
Common Name English
PRINZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYDROPRES
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYDRALAZINE HYDROCHLORIDE-HYDROCHLOROTHIAZIDE-RESERPINE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF MONOPRIL HCT
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF DIOVAN HCT
Common Name English
UNIRETIC COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF ACCURETIC
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF APRESOLINE-ESIDRIX
Common Name English
APRESAZIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
IRBESARTAN/HYDROCHLOROTHIAZIDE TEVA COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
APRESAZIDE
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF VISKAZIDE
Common Name English
HYDRO-RIDE COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
DIHYDROCHLORURITE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF EXFORGE HCT
Common Name English
DIOVAN HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HCT
Common Name English
HYDROSERPINE PLUS (R-H-H) COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HH-50/50
Common Name English
H.R.-50 COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
ZESTORETIC COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROPRES COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDE [EMA EPAR]
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF TEKTURNA HCT
Common Name English
IRBESARTAN/HYDROCHLOROTHIAZIDE-BMS COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
LOTENSIN HCT
Common Name English
MICARDISPLUS COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
EXFORGE HCT COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
COPALIA-HCT
Brand Name English
ACCURETIC COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
ALDORIL COMPONENT HYDROCHLOROTHIAZIDE
Common Name English
HYDROCHLOROTHIAZIDUM [WHO-IP LATIN]
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF ZIAC
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF RIPRAZO
Brand Name English
HIDROTIAZIDA
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF SER-AP-ES
Common Name English
NEWTOLIDE
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF ALDACTAZIDE
Common Name English
EXFORGE-HCT
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF HYDRAP-ES
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF MODURETIC
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF SPRIMEO-HCT
Brand Name English
TOLUCOMBI COMPONENT HYDROCHLOROTHIAZIDE
Brand Name English
HYDROCHLOROTHIAZIDE COMPONENT OF MICARDIS HCT
Common Name English
HYDROCHLOROTHIAZIDE COMPONENT OF PRINZIDE
Common Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS RASITRIO (WITHDRAWN: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS TOLUCOMBI (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS IBERSARTAN/HYDROCHLOROTHIAZIDE ZENTIVA (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C03AB03
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS IBERSARTAN/HYDROCHLOROTHIAZIDE-BMS (WITHDRAWN: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
NDF-RT N0000166469
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC09DX01
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS SPRIMEO-HCT (WITHDRAWN: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS EXFORGE-HCT (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC09DX03
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS KINZALKOMB (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS KARVEZIDE (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C09XA52
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS RASILEZ-HCT (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ESSENTIAL MEDICINES LIST 12.3
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
IARC Hydrochlorothiazide
EMA ASSESSMENT REPORTS IMPRIDA-HCT (WITHDRAWN: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS MICARDISPLUS (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C03AA03
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC03EA01
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS PRITORPLUS (AUTHORIZED: HYPERTENSION0
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C09XA54
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC03AA03
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C03EA01
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C09DX01
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C09BX03
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
NDF-RT N0000175419
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC09XA52
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS RIPRAZO-HCT (WITHDRAWN: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ESSENTIAL MEDICINES LIST 12.4
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC03AX01
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
LIVERTOX 483
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS IBERSARTAN/HYDROCHLOROTHIAZIDE TEVA (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ESSENTIAL MEDICINES LIST 16
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
NDF-RT N0000175359
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS COPALIA-HCT (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC09XA54
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS IFIRMACOMBI (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-VATC QC03AB03
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
CFR 21 CFR 522.1150
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C09DX03
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
NDF-RT N0000166469
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
NCI_THESAURUS C49185
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
EMA ASSESSMENT REPORTS DAFIRO-HCT (AUTHORIZED: HYPERTENSION)
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C09DX06
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
WHO-ATC C03AX01
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
Code System Code Type Description
CAS
8049-49-8
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
SUPERSEDED
DRUG BANK
DB00999
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
WIKIPEDIA
HYDROCHLOROTHIAZIDE
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
RXCUI
5487
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY RxNorm
EPA CompTox
58-93-5
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
HYDROCHLOROTHIAZIDE
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Very slightly soluble in water; practically insoluble in ether R; soluble in 200 parts of ethanol (~750 g/l) TS and in 20 parts of acetone R. Category: Diuretic. Storage: Hydrochlorothiazide should be kept in a well-closed container. Definition: Hydrochlorothiazide contains not less than 98.0% and not more than 102.0% of C7H8ClN3O4S2, calculated with reference to the dried substance.
HSDB
58-93-5
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
LactMed
58-93-5
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
CAS
58-93-5
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
NCI_THESAURUS
C29098
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
MESH
D006852
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
MERCK INDEX
M6089
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY Merck Index
INN
841
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
EVMPD
SUB08062MIG
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
PUBCHEM
3639
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
ECHA (EC/EINECS)
200-403-3
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
ChEMBL
CHEMBL435
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
IUPHAR
4836
Created by admin on Mon Oct 21 20:42:24 UTC 2019 , Edited by admin on Mon Oct 21 20:42:24 UTC 2019
PRIMARY
Related Record Type Details
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
EP
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
EXCRETED UNCHANGED
URINE
TRANSPORTER -> INHIBITOR
DERIVATIVE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC