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Details

Stereochemistry RACEMIC
Molecular Formula C11H12Cl2N2O
Molecular Weight 259.132
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LOFEXIDINE

SMILES

CC(OC1=C(Cl)C=CC=C1Cl)C2=NCCN2

InChI

InChIKey=KSMAGQUYOIHWFS-UHFFFAOYSA-N
InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)

HIDE SMILES / InChI

Approval Year

PMID

PMID

TitleDatePMID
Animal experiments on the safety pharmacology of lofexidine.
1982
Alcohol withdrawal syndromes: clinical management with lofexidine.
1985 Mar-Apr
Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal.
1997 Nov 25
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
1998 May 1
A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.
2004 Jun
Evidence-based addiction medicine: the use of lofexidine for opioid detoxification.
2004 Nov
QT interval increased after single dose of lofexidine.
2004 Nov 6
Alpha2 adrenergic agonists for the management of opioid withdrawal.
2004 Oct 18
A comparison of buprenorphine and lofexidine for community opiate detoxification: results from a randomized controlled trial.
2005 Dec
Lofexidine for opioid detoxification.
2005 Jan
Is clonidine useful for treatment of clozapine-induced sialorrhea?
2005 Jul
Induction of patients with moderately severe methadone dependence onto buprenorphine.
2005 Jun
Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats.
2005 May
Cognitive function during early abstinence from opioid dependence: a comparison to age, gender, and verbal intelligence matched controls.
2006 Feb 24
Opioid antagonists with minimal sedation for opioid withdrawal.
2006 Jan 25
Opiate addiction in China: current situation and treatments.
2006 May
The place of detoxification in treatment of opioid dependence.
2006 May
Pharmacologic treatments for opioid dependence: detoxification and maintenance options.
2007
In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone.
2007 Apr 17
Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study.
2007 Aug
The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project pilot study: protocol for a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification.
2007 Jan 8
Buprenorphine versus dihydrocodeine for opiate detoxification in primary care: a randomised controlled trial.
2007 Jan 8
Opioid dependence.
2007 Jun 1
Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings.
2007 Mar
A comparative clinical study of the effects of the traditional Chinese medicine Jinniu capsules and lofexidine on acute heroin withdrawal symptoms.
2008
Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis.
2008
Tai-Kang-Ning, a Chinese herbal medicine formula, alleviates acute heroin withdrawal.
2008
Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse.
2008 Mar
Agenda for specialty section in addiction medicine.
2008 Oct
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans.
2008 Sep
A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal.
2008 Sep 1
A study on Fu-Yuan Pellet, a traditional chinese medicine formula for detoxification of heroin addictions.
2009
Urine and plasma pharmacokinetics of lofexidine after oral delivery in opiate-dependent patients.
2009
Pharmacotherapy for cannabis dependence: how close are we?
2009
Norepinephrine and stimulant addiction.
2009 Apr
Alpha2-adrenergic agonists for the management of opioid withdrawal.
2009 Apr 15
The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification.
2009 Feb 5
Pharmacokinetics of lofexidine hydrochloride in healthy volunteers.
2009 Jan
The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) Prisons Project Study: protocol for a randomised controlled trial comparing methadone and buprenorphine for opiate detoxification.
2009 Jul 14
Opioid dependence.
2009 Jul 24
Buprenorphine for the management of opioid withdrawal.
2009 Jul 8
Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study.
2009 May
Opioid antagonists with minimal sedation for opioid withdrawal.
2009 Oct 7
Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients.
2009 Sep
A double-blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow-release oral morphine versus methadone in opioid-dependent in-patients willing to undergo detoxification.
2009 Sep
A case report of inpatient detoxification after kratom (Mitragyna speciosa) dependence.
2010
A comparison of methadone, buprenorphine and alpha(2) adrenergic agonists for opioid detoxification: a mixed treatment comparison meta-analysis.
2010 Apr 1
Lofexidine, an {alpha}2-receptor agonist for opioid detoxification.
2010 Feb
The pharmacological treatment of opioid addiction--a clinical perspective.
2010 Jun
Clonidine in adults as a sedative agent in the intensive care unit.
2010 Oct
Name Type Language
LOFEXIDINE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
LOFEXIDINE [VANDF]
Common Name English
LOFEXIDINE [WHO-DD]
Common Name English
LOFEXIDINE [MI]
Common Name English
1H-IMIDAZOLE, 2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-4,5-DIHYDRO-
Systematic Name English
2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-2-IMIDAZOLINE
Systematic Name English
LOFEXIDINE [INN]
Common Name English
Classification Tree Code System Code
WHO-ATC N07BC04
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
WHO-VATC QN07BC04
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
Code System Code Type Description
MERCK INDEX
M6885
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY Merck Index
EPA CompTox
31036-80-3
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
NCI_THESAURUS
C87578
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
MESH
C025655
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
ChEMBL
CHEMBL17860
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
EVMPD
SUB08558MIG
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
DRUG BANK
DB04948
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
CAS
31036-80-3
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
PUBCHEM
30668
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY SWITZERF
INN
3766
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
RXCUI
28863
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY RxNorm