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Details

Stereochemistry ACHIRAL
Molecular Formula C16H10FN3
Molecular Weight 262.2716
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLORTAUCIPIR F-18

SMILES

[18F]C1=CC=C(C=N1)C2=CC=C3C(NC4=C3C=NC=C4)=C2

InChI

InChIKey=GETAAWDSFUCLBS-SJPDSGJFSA-N
InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H/i17-1

HIDE SMILES / InChI

Description

Flortaucipir (18F-AV-1451, also known as 18F-T807) is a highly selective positron emission tomography (PET) imaging agent targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease, as well as in healthy subjects.

CNS Activity

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
14.6 nM [Kd]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
PubMed

PubMed

TitleDatePubMed
Synthesis and quality control of [(18) F]T807 for tau PET imaging.
2016 Aug
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition.
2017 Mar 1
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Flortaucipir PET images were acquired for 20 min, as four 5-min frames, beginning 80 min after injection of 370 MBq flortaucipir. On a separate day, subjects underwent a florbetapir PET scan for 10 min, as two 5-min frames, beginning 50 min after injection of 370 MBq florbetapir F18.
Route of Administration: Parenteral
Name Type Language
FLORTAUCIPIR F-18
Common Name English
FLORTAUCIPIR F 18
USAN  
USAN  
Official Name English
LY3191748
Code English
7-(6-(F-18)FLUOROPYRIDIN-3-YL)-5H-PYRIDO(4,3-B)INDOLE
Common Name English
T807 F-18
Code English
FLORTAUCIPIR F 18 [USAN]
Common Name English
(F-18)T807
Code English
AV-1451 F-18
Code English
18F-AV-1451
Code English
FLORTAUCIPIR (18F) [INN]
Common Name English
T-807 F-18
Code English
FLORTAUCIPIR (18F) [WHO-DD]
Common Name English
FLORTAUCIPIR (18F)
INN   WHO-DD  
INN  
Official Name English
LY-3191748
Code English
Code System Code Type Description
PUBCHEM
70957463
Created by admin on Mon Oct 21 22:49:52 UTC 2019 , Edited by admin on Mon Oct 21 22:49:52 UTC 2019
PRIMARY
CAS
1522051-90-6
Created by admin on Mon Oct 21 22:49:52 UTC 2019 , Edited by admin on Mon Oct 21 22:49:52 UTC 2019
PRIMARY
INN
10203
Created by admin on Mon Oct 21 22:49:52 UTC 2019 , Edited by admin on Mon Oct 21 22:49:52 UTC 2019
PRIMARY
ChEMBL
CHEMBL3546271
Created by admin on Mon Oct 21 22:49:52 UTC 2019 , Edited by admin on Mon Oct 21 22:49:52 UTC 2019
PRIMARY