U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C12H14N2.2ClH
Molecular Weight 259.175
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-(1-NAPHTHYL)ETHYLENEDIAMINE DIHYDROCHLORIDE

SMILES

Cl.Cl.NCCNC1=C2C=CC=CC2=CC=C1

InChI

InChIKey=MZNYWPRCVDMOJG-UHFFFAOYSA-N
InChI=1S/C12H14N2.2ClH/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12;;/h1-7,14H,8-9,13H2;2*1H

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
58.0 nM [Ki]
61.0 nM [Ki]
48.0 nM [Ki]
PubMed

PubMed

TitleDatePubMed
Micellar effects on dediazoniation and on azo coupling reactions.
2002 Apr 1
Test strip for determination of nitrite in water.
2002 Jul
Spectrophotometric determination of metronidazole and tinidazole in pharmaceutical preparations.
2002 May 15
The application of the chromatomembrane cell for the absorptive sampling of nitrogen dioxide followed by continuous determination of nitrite using a micro-flow injection system.
2002 May 16
Optimum conditions for effective use of the terminating ion in transient isotachophoresis for capillary zone electrophoretic determination of nitrite and nitrate in seawater, with artificial seawater as background electrolyte.
2002 Nov
Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation.
2003
Dietary nitrate and nitrite levels in an endemic upper gastrointestinal (esophageal and gastric) cancer region of Turkey.
2003 Mar
Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation.
2004 Apr 21
Flow-injection simultaneous determination of selenium(IV) and selenium(IV + VI) using photooxidative coupling of p-hydrazinobensenesulfonic acid with N-(1-naphthyl)ethylenediamine.
2004 Dec 15
Homocysteine and nitric oxide levels in plasma of patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and primary open-angle glaucoma.
2005 Jul
Proinflammatory liver and antiinflammatory intestinal mediators involved in portal hypertensive rats.
2005 Jun 9
Effect of aspect ratio on chemical reactions on microchip.
2006
High-density assembly of gold nanoparticles on multiwalled carbon nanotubes using 1-pyrenemethylamine as interlinker.
2006 Feb 9
Development of a detection tablet for a portable NO2 monitoring system.
2006 May
Selective determination of mimosine and its dihydroxypyridinyl derivative in plant systems.
2006 Oct
Inhibitory effect of inflexinol on nitric oxide generation and iNOS expression via inhibition of NF-kappaB activation.
2007
Spectrophotometric determination of V(V) in environmental, biological, pharmaceutical and alloy samples by novel oxidative coupling reactions.
2007 Feb 9
Application of genomic biomarkers to predict increased lung tumor incidence in 2-year rodent cancer bioassays.
2007 May
Effects of nebulized ketamine on allergen-induced airway hyperresponsiveness and inflammation in actively sensitized Brown-Norway rats.
2007 May 4
Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats.
2008 Aug 9
A rapid technique for determination of nitrate and nitric acid by acid reduction and diazotization at elevated temperature.
2008 Jul 14
Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation.
2008 Jul 15
Natriuretic peptides modify Pseudomonas fluorescens cytotoxicity by regulating cyclic nucleotides and modifying LPS structure.
2008 Jul 9
Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro.
2008 Jun 13
Development and validation of spectrophotometric methods for determination of ceftazidime in pharmaceutical dosage forms.
2008 Sep
Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models.
2008 Sep 2
Purification and characterization of a lectin from Phaseolus vulgaris cv. (Anasazi beans).
2009
Alternative spectrofluorimetric determination of short-chain volatile fatty acids in aqueous samples.
2009 Apr 15
Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine.
2009 Apr-Jun
Acute seizure activity promotes lipid peroxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum.
2009 Jul-Aug
Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages.
2009 Jun
Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex.
2009 Mar
Estimation of nitric oxide as an inflammatory marker in periodontitis.
2009 May
Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity.
2009 Sep-Oct
Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.
2010
The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis.
2010
Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB.
2010 Apr
Resveratrol differentially modulates inflammatory responses of microglia and astrocytes.
2010 Aug 17
Vaccination of mice with salmonella expressing VapA: mucosal and systemic Th1 responses provide protection against Rhodococcus equi infection.
2010 Jan 13
Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion.
2010 Jun 1
Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance.
2010 Jun 30
Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-α and Nitric Oxide Production In Vitro.
2010 Mar
Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata.
2010 May 11
On-line analysis of volatile fatty acids in anaerobic treatment processes.
2010 May 23
EGb761 protects motoneurons against avulsion-induced oxidative stress in rats.
2010 May 24
Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice.
2010 May 7
Patents

Patents

Name Type Language
N-(1-NAPHTHYL)ETHYLENEDIAMINE DIHYDROCHLORIDE
MI  
Systematic Name English
REAGENTS, BRATTON-MARSHALL
Brand Name English
N-(1-NAPHTHYL)ETHYLENEDIAMINE DIHYDROCHLORIDE [MI]
Common Name English
N-(1-NAPTHYL)ETHYLENE DIAMINE DIHYDROCHLORIDE [HSDB]
Common Name English
NSC-9849
Code English
N-NAPHTHYLETHYLENEDIAMINE DIHYDROCHLORIDE
Systematic Name English
ETHYLENEDIAMINE, N-1-NAPHTHYL-, DIHYDROCHLORIDE
Common Name English
1,2-ETHANEDIAMINE, N-1-NAPHTHALENYL-, DIHYDROCHLORIDE
Common Name English
BRATTON-MARSHALL REAGENT
Brand Name English
1,2-ETHANEDIAMINE, N1-1-NAPHTHALENYL-, HYDROCHLORIDE (1:2)
Systematic Name English
Code System Code Type Description
MERCK INDEX
M7761
Created by admin on Tue Oct 22 13:36:11 UTC 2019 , Edited by admin on Tue Oct 22 13:36:11 UTC 2019
PRIMARY Merck Index
HSDB
1465-25-4
Created by admin on Tue Oct 22 13:36:11 UTC 2019 , Edited by admin on Tue Oct 22 13:36:11 UTC 2019
PRIMARY
MESH
C008588
Created by admin on Tue Oct 22 13:36:11 UTC 2019 , Edited by admin on Tue Oct 22 13:36:11 UTC 2019
PRIMARY
CAS
1465-25-4
Created by admin on Tue Oct 22 13:36:11 UTC 2019 , Edited by admin on Tue Oct 22 13:36:11 UTC 2019
PRIMARY
ECHA (EC/EINECS)
215-981-2
Created by admin on Tue Oct 22 13:36:11 UTC 2019 , Edited by admin on Tue Oct 22 13:36:11 UTC 2019
PRIMARY
EPA CompTox
1465-25-4
Created by admin on Tue Oct 22 13:36:11 UTC 2019 , Edited by admin on Tue Oct 22 13:36:11 UTC 2019
PRIMARY