Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H26N7O8P |
| Molecular Weight | 583.4898 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2C(=CN(COP(O)(O)=O)C2=C(N=C1)N3C=NC(C)=N3)C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5
InChI
InChIKey=SWMDAPWAQQTBOG-UHFFFAOYSA-N
InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38)
Fostemsavir (BMS-663068) is an investigational attachment inhibitor with a unique mechanism of action. It is a prodrug of temsavir, which binds to HIV envelope glycoprotein 120 (gp120), thereby preventing viral attachment to the host CD4 cell surface receptor. In the absence of effective binding of HIV gp120 with the host CD4 receptor, HIV does not enter the host cell. Because fostemsavir has a novel mechanism of action, the drug should have full activity against HIV strains that have developed resistance to other classes of antiretroviral medications. In a phase 2b study of treatment-experienced individuals, fostemsavir appeared to be well tolerated. Phase 3 studies are ongoing.
Originator
Approval Year
Sample Use Guides
A phase 2b trial enrolled treatment-experienced adults with HIV infection and randomized study subjects to one of four doses of fostemsavir (400 mg twice daily, 800 mg twice daily, 600 mg once daily, or 1200 mg once daily).
Route of Administration:
Oral
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11319217
Created by
admin on Mon Oct 21 22:59:19 UTC 2019 , Edited by admin on Mon Oct 21 22:59:19 UTC 2019
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PRIMARY | |||
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CHEMBL3301594
Created by
admin on Mon Oct 21 22:59:19 UTC 2019 , Edited by admin on Mon Oct 21 22:59:19 UTC 2019
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10292
Created by
admin on Mon Oct 21 22:59:19 UTC 2019 , Edited by admin on Mon Oct 21 22:59:19 UTC 2019
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PRIMARY | |||
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864953-29-7
Created by
admin on Mon Oct 21 22:59:19 UTC 2019 , Edited by admin on Mon Oct 21 22:59:19 UTC 2019
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PRIMARY | |||
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864953-29-7
Created by
admin on Mon Oct 21 22:59:19 UTC 2019 , Edited by admin on Mon Oct 21 22:59:19 UTC 2019
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PRIMARY |
ACTIVE MOIETY
METABOLITE ACTIVE (PRODRUG)
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
