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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H19BrN4O2
Molecular Weight 439.305
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of REMIMAZOLAM

SMILES

COC(=O)CC[C@@H]1N=C(C2=CC=CC=N2)C3=CC(Br)=CC=C3N4C(C)=CN=C14

InChI

InChIKey=CYHWMBVXXDIZNZ-KRWDZBQOSA-N
InChI=1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1

HIDE SMILES / InChI

Description

Remimazolam is an intravenous benzodiazepine sedative-hypnotic with rapid onset and offset of action. This compound undergoes organ-independent metabolism to an inactive metabolite. Like other benzodiazepines, remimazolam can be reversed with flumazenil to rapidly terminate sedation and anesthesia. Phase I and II clinical trials have shown that remimazolam is safe and effective when used for procedural sedation. Phase III clinical trials have been completed investigating efficacy and safety in patients undergoing bronchoscopy and colonoscopy. The developer of this drug has suggested that intensive care unit sedation (beyond 24 hours) could be another possible indication for further development, since it is unlikely that prolonged infusions or higher doses of remimazolam would result in accumulation and extended effect.

CNS Activity

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Name Type Language
REMIMAZOLAM
INN   WHO-DD  
INN  
Official Name English
METHYL 3-((4S)-8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-4-YL)PROPANOATE
Systematic Name English
CNS 7056
Code English
CNS-7056
Code English
REMIMAZOLAM [INN]
Common Name English
ONO-2745
Code English
REMIMAZOLAM [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1012
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
Code System Code Type Description
INN
9232
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
PRIMARY
MESH
C522201
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
PRIMARY
NCI_THESAURUS
C152187
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
PRIMARY
WIKIPEDIA
REMIMAZOLAM
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
PRIMARY
PUBCHEM
9867812
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
PRIMARY
EVMPD
SUB178714
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
PRIMARY
CAS
308242-62-8
Created by admin on Mon Oct 21 23:46:30 UTC 2019 , Edited by admin on Mon Oct 21 23:46:30 UTC 2019
PRIMARY