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Details

Stereochemistry RACEMIC
Molecular Formula C11H11NO2
Molecular Weight 189.2105
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENSUXIMIDE

SMILES

CN1C(=O)CC(C1=O)C2=CC=CC=C2

InChI

InChIKey=WLWFNJKHKGIJNW-UHFFFAOYSA-N
InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3

HIDE SMILES / InChI

Description

Phensuximide is an anticonvulsant in the succinimide class. For the treatment of epilepsy. Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. Phensuximide's mechanism of action not understood, but may act in inhibitory neuronal systems that are important in the generation of the three per second rhythm. It's effects may be related to its ability to inhibit depolarization-induced accumulation of cyclic AMP and cyclic GMP in brain tissue.

Originator

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
MILONTIN
PubMed

PubMed

TitleDatePubMed
Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide.
1963 Mar
Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain.
1979 Jun
Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat.
1986 Oct
Name Type Language
PHENSUXIMIDE
INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INN  
Official Name English
SUCCITIMAL
Common Name English
MILONTON
Common Name English
PHENSUXIMIDE [ORANGE BOOK]
Common Name English
SUCCINIMIDE, N-METHYL-2-PHENYL-
Systematic Name English
PHENSUXIMIDE [VANDF]
Common Name English
1-METHYL-3-PHENYLSUCCINIMIDE
Common Name English
(+/-)-N-METHYL-2-PHENYLSUCCINIMIDE
Systematic Name English
N-METHYL-3-PHENYLSUCCINIMIDE
Systematic Name English
MILONTIN
Brand Name English
1-METHYL-3-PHENYL-2,5-PYRROLIDINEDIONE
Systematic Name English
PHENSUXIMIDE [USP]
Common Name English
2,5-PYRROLIDINEDIONE, 1-METHYL-3-PHENYL-
Systematic Name English
PHENSUXIMIDE [USP-RS]
Common Name English
PHENSUXIMIDE [WHO-DD]
Common Name English
(+/-)-PHENSUXIMIDE
Common Name English
PHENSUXIMID
Common Name English
2,5-PYRROLIDINEDIONE, 1-METHYL-3-PHENYL-, (+/-)-
Systematic Name English
LIFENE
Common Name English
PHENSUXIMIDE [MART.]
Common Name English
RACEMIC PHENSUXIMIDE
Common Name English
N-METHYL-.ALPHA.-PHENYLSUCCINIMIDE
Common Name English
MIRONTIN
Common Name English
EPIMID
Brand Name English
N-METHYL-3-PHENYLPYRROLIDINEDIONE
Common Name English
N-METHYL-2-PHENYLSUCCINIMIDE
Systematic Name English
RS-PHENSUXIMIDE
Systematic Name English
PHENSUXIMIDE [MI]
Common Name English
PM-334
Code English
PHENSUXIMIDE [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QN03AD02
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
WHO-ATC N03AD02
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
Code System Code Type Description
INN
513
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
WIKIPEDIA
PHENSUXIMIDE
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
MERCK INDEX
M8643
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY Merck Index
ECHA (EC/EINECS)
201-664-6
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
CAS
34367-67-4
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
SUPERSEDED
NCI_THESAURUS
C66375
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
CAS
86-34-0
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
EPA CompTox
86-34-0
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
RXCUI
33309
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY RxNorm
EVMPD
SUB09783MIG
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
ChEMBL
CHEMBL797
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
PUBCHEM
6839
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY SWITZERF
DRUG BANK
DB00832
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY
MESH
C100129
Created by admin on Tue Mar 06 12:24:41 UTC 2018 , Edited by admin on Tue Mar 06 12:24:41 UTC 2018
PRIMARY