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Details

Stereochemistry ACHIRAL
Molecular Formula C16H26N5O8.Dy
Molecular Weight 578.904
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SPRODIAMIDE

SMILES

CN=C(CN(CCN(CCN(CC(=NC)[O-])CC(=O)O)CC(=O)[O-])CC(=O)O)[O-].[Dy+3]

InChI

InChIKey=ABWHOEHSTSEVRD-UHFFFAOYSA-K
InChI=1S/C16H29N5O8.Dy/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);/q;+3/p-3

HIDE SMILES / InChI
Sprodiamide is a nonionic paramagnetic dysprosium chelate agent patented by Salutar, Inc.as diagnostic imaging contrast media. Compare with gadolinium-based agents Sprodiamide shows a stronger T2 effect and negligible T1 effect. This property makes Sprodiamide useful for blood volume imaging. In a preclinical model of reperfused ischemia of the rat intestine administration of Sprodiamide improved the contrast between the normal and ischemic intestine on T2-weighted images, and administration of both gadodiamide and Sprodiamide improved the contrast on T1- and T2-weighted images.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

0.1, 0.2, and 0.3 mmol/kg, at rates of 2 ml/second and 5 ml/second
Route of Administration: Intravenous
Name Type Language
SPRODIAMIDE
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
SPRODIAMIDE [INN]
Common Name English
SPRODIAMIDE [WHO-DD]
Common Name English
S-043
Code English
DYDTPA-BMA
Code English
DYSPROSIUM, (5,8-BIS(CARBOXYMETHYL)-11-(2-(METHYLAMINO)-2-OXOETHYL)-3-OXO-2,5,8,11-TETRAAZATRIDECAN-13-OATO(3-))-
Common Name English
SPRODIAMIDE ANHYDROUS
Common Name English
SPRODIAMIDE [USAN]
Common Name English
(N,N-BIS(2-((CARBOXYMETHYL)((METHYLCARBAMOYL)METHYL)AMINO)ETHYL)GLYCINATO(3-))DYSPROSIUM
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C390
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
Code System Code Type Description
EPA CompTox
128470-17-7
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
PRIMARY
FDA UNII
0E6DA2DHBE
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
PRIMARY
NCI_THESAURUS
C81060
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
PRIMARY
PUBCHEM
72052
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
PRIMARY
EVMPD
SUB10638MIG
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
PRIMARY
INN
7136
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
PRIMARY
CAS
128470-17-7
Created by admin on Sat Jun 26 16:39:23 UTC 2021 , Edited by admin on Sat Jun 26 16:39:23 UTC 2021
PRIMARY